Skip to main content
Skip to main menu


Kaixiong (Calvin) Ye

Blurred image of the arch used as background for stylistic purposes.
Assistant Professor
PhD (2015) Cornell University
Research Interests:

My research interest lies in Nutritional Genomics, a new interdisciplinary field bridging Nutritional Sciences and Human Genomics. I am interested in identifying genetic variants that historically helped human populations adapted to local diets and currently underlie individual differences in nutrient metabolism and metabolic disease risks. In the long run, I hope to develop statistical methods that integrate genomic information to personalized our dietary recommendation (Personalized Nutrition).  Current research topics in my lab include:

1) Genetic adaptation to diet during human evolution (Population Genomics)
2) Evolution of metabolic genes (Comparative Genomics)
3) Genetic basis of metabolic diseases (Quantitative Genomics; Medical Genetics)
4) Molecular mechanism of genetic variants (Molecular Genetics)
5) Gene-diet interaction in metabolic diseases (Quantitative Genomics; Genetic Epidemiology)

Selected Publications:

Francis M, Li C, Sun Y, Zhou J, Li X, Brenna JT, Ye K^. Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci. PLOS Genetics. (2021)

Zhou J, Sun Y, Huang W, Ye K^. Altered blood cell traits underlie a major genetic locus of severe COVID-19. Journal of Gerontology: Medical Sciences. (2021)

Zhou J, Liu C, Sun Y, Huang W, Ye K^. Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain, Behavior, and Immunity (2020)

Zhou J, Liu C, Francis M, Sun Y, Ryu MS, Grider A, Ye K^. The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-wide Mendelian Randomization Study. Nutrients. (2020)

Ye K, Gao F, Wang D, Bar-Yosef O, Keinan A. Dietary adaptation of FADS genes in Europe varied across time and geography. Nature Ecology and Evolution (2017)

Kothapalli KSD*, Ye K*, Gadgil MS, et al. Positive selection on a regulatory insertion–deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid. Molecular Biology and Evolution (2016).

Ye K*, Cao C*, Lin X, O'Brien KO, Gu Z. Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption. BMC Genetics (2015).

Ye K^, Lu J, Ma F, Keinan A, Gu Z^. Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals. Proceedings of the National Academy of Sciences (2014).

Ye K^, Lu J, Raj SM, Gu Z^. Human expression QTLs are enriched in signals of environmental adaptation. Genome Biology and Evolution (2013).

Ye K & Gu Z. Recent advances in understanding the role of nutrition in human genome evolution. Advances in Nutrition (2011).

Articles Featuring Kaixiong (Calvin) Ye
Tuesday, August 31, 2021 - 11:03am

University of Georgia researcher Kaixiong Ye has received a Maximizing Investigators Research Award from the National Institutes of Health. The nearly $2 million, five-year award will support efforts to characterize gene-environment…

Friday, March 26, 2021 - 9:24am

Fish oil supplements are a billion-dollar industry built on a foundation of purported, but not proven, health benefits. Now, new research from a team led by a University of Georgia scientist indicates that taking fish oil only provides health benefits if you…

Wednesday, October 28, 2020 - 5:00pm

A team in the Franklin College of Arts and Sciences Department of Genetics, led by Assistant Professor Kaixiong Ye and his postdoc, Jingqi Zhou, has published a long-term study of more than 500,000 participants investigating the respective contributions of…

Graduate Students

Yitang Sun

Doctoral Student

Huifang Xu

Doctoral Student

Shuang Yang

Doctoral Student

Support Genetics at UGA

Thank you for your support to the Genetics Department and the University of Georgia. Contributions from alumni and friends are critical to maintaining our core missions of teaching and research. Gifts are tax deductible.

Click here to learn more

Every dollar contributed to the department has a direct impact on our students and faculty.