Skip to main content
Skip to main menu

Slideshow

Tania Rozario

Blurred image of the arch used as background for stylistic purposes.
Assistant Professor

As a developmental biologist, I have been fascinated by the extraordinary physiological capabilities of parasites like tapeworms. Tapeworms are well known for the enormous lengths they reach, which often elicit freak headlines in popular media. The success of these parasites is largely enabled by stem cells that drive growth, regeneration, and prolific reproduction and my lab's research seeks to uncover the molecular mechanisms that regulate these feats. 

 

We have (re)established the rat tapeworm, Hymenolepis diminuta, as a tractable model organism. This species was a favorite model among parasitologists in the early-mid 20th century but was left behind by the molecular biology revolution. We have developed tools such as transcriptomics, in vitro culture, in situ hybridization, and RNA interference and are continuing to advance this model with additional genetic tool-building. With these techniques in hand, we seek to answer several fundamental questions that elucidate tapeworm biology: How is tapeworm regeneration regulated? What are the signals that promote or restrict regenerative potential? How is the tapeworm stem cell niche established and maintained? What are the mechanisms that segregate germ cells from somatic stem cells and how is this coordinated with segment generation? How does the tapeworm elaborate its hermaphroditic reproductive system? These big-picture questions motivate our lab's research and hold the potential for future translation into medical interventions that treat tapeworm infections.

Education:

Ph.D. (2012) University of Virginia

Research Interests:

Cell Biology

Developmental Biology

Regenerative Medicine

Selected Publications:

Rozario T, Quinn EB, Wang JB, Davis RE, Newmark PA. 2019. Region-specific regulation of stem cell-driven regeneration in tapeworms. eLife 8:e48958. PMID: 31549962

Rozario T, Newmark PA. 2015. A confocal microscopy-based atlas of tissue architecture in the tapeworm Hymenolepis diminutaExp Parasitol 158: 31-41. PMID: 26049090

Support Genetics at UGA

Thank you for your support to the Genetics Department and the University of Georgia. Contributions from alumni and friends are critical to maintaining our core missions of teaching and research. Gifts are tax deductible.

Click here to learn more

Every dollar contributed to the department has a direct impact on our students and faculty.