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David Garfinkel

Blurred image of the arch used as background for stylistic purposes.
Professor of Biochemistry and Molecular Biology
Ph.D. (1981) University of Washington
  • Grant Support -
    • "Antisense RNAs control retrotransposon movement", NIH
Selected Publications:
  • Purzycka, K.J., M. Legiewicz, E. Matsuda, L.D. Eizentstat, S. Lusvarghi, A. Saha, S.F. Le Grice and D.J. Garfinkel. Exploring Ty1 retrotransposon RNA structure within virus-like paticles. 2013. Nucleic Acids Res. 41(1): 463-73.
  • Checkley, M.A., J.A. Mitchell, L.D. Eizenstat, S.J. Lockett, and D.J Garfinkel.  2012.  Ty1 Gag mediates the accumulation and nuclear export of Ty1 mRNA. 2013. Traffic 14(1): 57-69.
  • Checkley, M. A., K. Nagashima, S. Lockett, and D. J. Garfinkel.  2010.  P-bodies are required for Ty1 retrotransposition during assembly of virus-like particles. Mol Cell Biol. 30:382-398.
  • Dakshinamurthy A., K.M. Nyswaner, P.J. Farabaugh, and D.J. Garfinkel.  2010.  BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae. Genetics 185:1193-1205.
  • Matsuda, E. and D. J. Garfinkel.  2009.  Posttranslational interference of Ty1 retrotransposition by antisense RNAs. Proc Natl Acad Sci USA. 106:15657-15662.
  • Moore, S. P. and D. J. Garfinkel.  2009.  Functional analysis of N-terminal residues of Ty1 integrase. J. Virol. 83:9502-9511.
  • Nyswaner, K.M., M.A. Checkley, M. Yi, R.M. Stephens, and D.J. Garfinkel.  2008.  Chromatin associated genes protect the yeast genome from Ty1 insertional mutagenesis. Genetics 178:197-214.
  • Curcio, M.J., A.E. Kenny, S. Moore, D.J. Garfinkel, M. Weintraub, E.R. Gamache and D.T. Scholes.  2007.  S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1. Mol Cell Biol. 27:8874-8885.
  • Garfinkel, D.J., Stefanisko K.M., Nyswaner K.M., Moore S.P., Oh J., and Hughes S.H.  2006. Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flap. J Virol. 80:11920-11934.
  • Asefa, B., J.M. Dermott, P. Kaldis, K.M. Stefanisko, D.J. Garfinkel, and J.R. Keller.  2006.  p205, A potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.  FEBS Letters 580:1205-1214.
  • Nissley, D.V., E. Halvas, N. Hoppman, D.J. Garfinkel, J. Mellors, and J.N. Strathern.  2005.  Sensitive phenotypic detection of minor drug resistant HIV-1 reverse transcriptase variants.  J. Clin. Micro. 43:5696-5704.
  • Garfinkel, D.J.  2005.  Genome evolution mediated by Ty elements in Saccharomyces.  Cytogenetics Genome Res. 110:63-69
  • Garfinkel, D.J., K.M. Nyswaner, K.M. Stefanisko, C. Chang, and S.P. Moore.  2005.  Ty1 copy number dynamics in Saccharomyces.  Genetics 169:1845-1857.
  • Moore, S.P., G. Liti, K.M. Stefanisko, K.M. Nyswaner, C. Chang, E.J. Louis, and D.J. Garfinkel.  2004.  Analysis of a Ty1-less variant of Saccharomyces paradoxus: the gain and loss of Ty1 elements.  Yeast 21:649-660.
  • Garfinkel, D.J.  2004.  When toothpicks mattered: using microbial genetics and transposon tagging to map the T-DNA.  In The Agrobacterium Anthology (E.W. Nester, M.P. Gordon, and A. Kerr eds.), American Phytopathological Society Press, St. Paul, MN.  pp. 116-129.
  • Sundararajan, A., B.S. Lee, and D.J. Garfinkel.  2003.  The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.  Genetics 163:55-67.
  • Martin, S.L. and D.J. Garfinkel.  2003.  Survival strategies for transposons and genomes. Genome Biol 4:313-315.
  • Garfinkel, D.J., K.M. Nyswaner, J. Wang, and J.-Y. Cho.  2003.  Post-transcriptional cosuppression of Ty1 retrotransposition. Genetics 165:83-99.
  • Giaever, G., et al.  2002.  Functional profiling of the S. cerevisiae genome.  Nature 418:387-391.
  • Garfinkel, D.J. and A.M. Bailis.  2002.  Nucleotide excision repair, genome stability, and human disease: New insight from model organisms.  J Biomed Biotechnol 2:55-60. 
  • Li, A., R.C. Sowder II, L.E. Henderson, S.P. Moore, D.J. Garfinkel, and R.J. Fisher.  2001.  Chemical cleavage at aspartyl residues for protein identification.  Anal Chem 73:5395-5402.
  • Rattray, A.L., B.K. Shafer, and D.J. Garfinkel.  2000.  The Saccharomyces cerevisiae DNA recombination and repair functions of the RAD52 epistasis group inhibit Ty1 transposition.  Genetics 154:543-556.
  • Moore, S.P. and D.J. Garfinkel.  2000.  Correct integration of model substrates by Ty1 inegrase.  J Virol 74:11522-1130.
  • Lee, BS, L. Bi, D.J. Garfinkel, and A.M. Bailis.  2000.  Nucleotide excision Repair/TFIIH helicases Rad3 and Ssl2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms.  Mol Cell Biol 20:2436-2445.
  • Feng, Y., S.P. Moore, D.J. Garfinkel, and A. Rein.  2000.  The genomic RNA in Ty1 virus-like particles is dimeric.  J Virol 74:10819-10821.

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