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Stephanie A. Herrlinger

B.S. Molecular Genetics
Graduate Student, Interdisiplinary Neuroscience PHD Program, BHSI

Brain development requires the precise temporal expression and function of proteins to dictate correct neural progenitor cell (NPC) behaviors. I study the RNA-binding protein Lin28 and its capacity to drive NPC fates at the post-transcriptional level during development.

NPCs have recently been discovered to be susceptible to infection and damage by the Zika virus during gestation. Our work has elucidated how the Zika virus may cause brain damage in part through disrupting neurovascular development and the blood brain barrier, as well as differences in the damage potential of different lineage isolates and Dengue virus infection in brain development. 

Awards & Funding: 

NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award (F99/K00) - 2017 - 2023

ARCS Foundation Fellowship - 2016 - 2019

NIH T32 Genetics Training Grant - 2016 - 2017

Erlanger Graduate Fellowship for Aging Research - 2015 - 2016

Graduate Student Assistantship - 2014 - 2016

Scholars of Excellence Fellowship - 2013 - 2014

Foundation Graduate Fellowship - 2013 - 2014

EGRF Award - 2013 - 2014

                                                   

Selected Publications:

Shao Q*, Herrlinger S*, Zhu YN, Yang M, Goodfellow F, Stice S, Qi XP, Brindley MA, Chen JF. The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus. Development 2017 : doi: 10.1242/dev.156752. 

http://dev.biologists.org/content/early/2017/10/09/dev.156752

Shao Q*, Herrlinger S*, Yang SL, Lai F, Moore JM, Brindley MA, Chen JF. Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage. Development. 2016 Oct 11. pii: dev.143768. 

http://dev.biologists.org/content/early/2016/10/08/dev.143768.long

Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Science Advances. 2016 Sept 1; 2(9):e1601167. 

http://advances.sciencemag.org/content/2/9/e1601167.abstract

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA. 2016. Human glia can both induce and rescue aspects of disease phenotype in Huntington disease. Nature Communications. 2016 Jun 7;7:11758. 

http://www.nature.com/ncomms/2016/160607/ncomms11758/full/ncomms11758.html

Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF. MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Developmental Biology. 2015 Dec 1;408(1):140-50. 

http://www.sciencedirect.com/science/article/pii/S0012160615301044

Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF. Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development. 2015 May 1;142(9):1616-27.

http://dev.biologists.org/content/142/9/1616.short

(* authors contributed equally to this work)

 

Arthur Edison

Professor
Eminent Scholar
Director
PhD (1993) University of Wisconsin-Madison
  • Grant Support -
    • Southeast Center for Integrated Metabolomics (NIH U24DK097209), 09/01/13-08/31/18. SECIM is one of 6 NIH centers for metabolomics. Prof. Edison was the founding PI and Director at the University of Florida, and he now in PI of a UGA subcontract for NMR metabolomics.
  • Research Interests -
    • The Edison lab uses metabolomics and natural products chemistry to understand the chemical basis of behavior. Our primary organism for this work is Caenorhabditis elegans, a small, free-living nematode. C. elegans has been one of the best studied animals in science, with an extensive genetics, anatomy, cell, and developmental biology knowledge-base. Less is known about the role of small molecules in its development and behavior, and our studies in metabolomics can leverage the extensive understanding of this worm. We also are very interested in other nematodes, including parasitic species. Prof. Edison got his start in nematodes as a postdoc working on Ascaris suum, a large intestinal pig parasite that is very similar to a related species, Ascaris lumbricoides, which infects about 1 billion people world-wide.
Selected Publications:

“Metabolomics and Natural Products Strategies to Study Chemical Ecology in Nematodes” Arthur S. Edison*, Chaevien Clendinen, Ramadan Ajredini, Chris Beecher, Francesca Ponce, and Gregory Stupp. In Press, Invited contribution to the Journal of Integrative and Comparative Biology (2015)
“An Overview of Methods for Improved Compound Identification in Metabolomics and Natural Products Using 13C.” Arthur S. Edison*, Chaevien S. Clendinen, Gregory S. Stupp+, Ramadan Ajredini, and Chris Beecher. In Press, Invited contribution to Frontiers in Plant Science (2015).
Chaevien S. Clendinen, Christian Pasquel, Ramadan Ajredini, Arthur S. Edison* “13C NMR Metabolomics: INADEQUATE Network Analysis”, Anal. Chem. 87(11), 5698-5706 (2015).
Menger, R. F. ‡, Clendinen, C.‡, Searcy, L. A., Edison, A. S., & Yost, R. A.*, “MALDI Mass Spectrometric Imaging of the Nematode Caenorhabditis elegans” Current Metabolomics 3, 130-137 (2015).
Frelin, O., Huang, L., Hasnain, G., Jeffryes, J. G., Ziemak, M. J., Rocca, J. R., Wang, B., Rice, J., Roje, S., Yurgel, S. N., Gregory, J. F., Edison, A. S., Henry, C. S., de Crecy-Lagard, V., and Hanson, A. D.* (2015) A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis., Biochem J 466, 137-145.
Clendinen, C. S., Lee-McMullen, B., Williams, C. M., Stupp, G. S., Vandenborne, K., Hahn, D. A., Walter, G. A., and Edison, A. S.* (2014) “¹³C NMR metabolomics: applications at natural abundance”, Analytical Chemistry 86, 9242-9250.
Williams, C. M., Watanabe, M., Guarracino, M. R., Ferraro, M. B., Edison, A. S., Morgan, T. J., Boroujerdi, A. F., and Hahn, D. A.* (2014) “Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster”, Evolution 68, 3505-3523.
Stupp, G.S., Clendinen, C., Ajredini, R., Szewc, M.A., Garrett, T., Menger, R.F., Yost, R.A., Beecher, C.* & Edison, A.S.* “Isotopic Ratio Outlier Analysis Global Metabolomics of Caenorhabditis elegans” Anal. Chem. 85, 11858-65 (2013).
Ramaswamy, V., Hooker, J.W., Withers, R.S., Nast, R.E., Brey, W.W*., Edison, A.S.* “Development of a 13C-Optimized 1.5-mm High Temperature Superconducting NMR Probe” J. Magn. Reson. 235C, 58–65. (2013).
Stupp, G. S., Reuss, von, S. H., Izrayelit, Y., Ajredini, R., Schroeder, F. C.*, and Edison, A. S.* (2013) “Chemical detoxification of small molecules by Caenorhabditis elegans” ACS chemical biology 8, 309–313. Featured in C&E News, Science and Technology Concentrates, Dec 3, 2012.
Choe, A.&, Chuman, T.&, von Reuss, S.H.&, Dossey, A.T.&, Yim, J., Ajredini, R., Kolawa, A.A., Kaplan, F., Alborn, H.T., Teal, P.E., Schroeder, F.C., Sternberg, P.W., & Edison, A.S.* “Gender-Specific Mating Pheromones in the Nematode Panagrellus redivivus”, PNAS 109, 20949-20954 (2012).
Fatma Kaplan; Hans T Alborn; Stephan H von Reuss; Ramadan Ajredini; Jared G Ali; Faruk Akyazi; Lukasz L Stelinski; Arthur S Edison; Frank C Schroeder; Peter E Teal*, "Interspecific nematode signals regulate dispersal behavior", PLoS One, 7(6), e38735, doi:10.1371/journal.pone.0038735 (2012).
Srinivasan, J., von Reuss, S.H., Bose, N., Mahanti, P., Ho, M.C., O’Doherty, O.G., Edison, A.S., Sternberg, P.W.* & Schroeder, F.C.*, “A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans”, PLoS Biol 10(1): e1001237. doi:10.1371/journal.pbio.1001237 (2012).
Robinette, S.L., Ajredini, R., Rasheed, H., Zeinomar, A., Schroeder F.C., Dossey, A.T., & Edison, A.S.*, “Hierarchical Alignment and Full Resolution Pattern Recognition of 2D NMR Spectra: Application to Nematode Chemical Ecology.”, Analytical Chemistry 83 (5), 1649–1657 (2011). PMID: 21314130
Kaplan, F., Srinivasan, J., Mahanti, P., Ajredini, R., Durak, O., Nimalendran, R., Sternberg, P.W., Teal, P.E.A, Schroeder, F.C., Edison, A.S., and Alborn, H.T.*, “Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage”, PLoS One 6(3):e17804, (2011). PMID: 21423575
Waller, J.C., Alvarez, S., Naponelli, V., Lara-Nuñez, A., Blaby, I.K., Da Silva, V., Ziemak, M.J., Vickers, T.J., Beverley, S.M., Edison, A.S., Rocca, J.R., Gregory III, J.F., de Crécy-Lagard, V., & Hanson, A.D.* “A Newly Discovered Role for Tetrahydrofolates in the Metabolismof Iron-Sulfur Clusters in All Domains of Life”, PNAS 107, 10412-72010 (2010). PMID: 20489182
Kaplan, F., Badri, D. V., Zachariah, C., Ajredini, R., Sandoval, F. J., Roje, S., Levine, L. H., Zhang, F., Robinette, S. L., Alborn, H. T., Zhao, W., Stadler, M., Nimalendran, R., Dossey, A. T., Brüschweiler, R. A., Vivanco, J. M., Edison, A. S.* “Bacterial Attraction and Quorum Sensing Inhibition in Caenorhabditis elegans Exudates”, Journal of Chemical Ecology 35(8):878-92 (2009). PMID: 19649780
Dossey, A. T.*, Gottardo, M., Whitaker, J., Roush, W. R., & Edison, A. S. “AlkylDimethylpyrazines in the Defensive Spray of Phyllium westwoodii: A First for Order Phasmatodea”, Journal of Chemical Ecology 35(8):861-70 (2009). PMID: 19685263. This is a cover article.
Dalisay, D. S., Rogers, E. W., Edison, A. S., Molinski, T. F.* Structure Elucidation at the Nanomole-Scale. Trisoxazole macrolides and Thiazole-containing cyclic peptides from the Nudibranch Hexabranchus sanguineus, Journal of Natural Products 72, 732-8 (2009). PMID: 19254038
Srinivasan, J., Kaplan, F., Ajredini, R., Zachariah, C., Alborn, H., Teal, P., Edison, A. S.*, Paul W. Sternberg, P. W.*, & Schroeder, F. C.* “A synergistic blend of small molecules differentially regulates both mating behavior and population density in Caenorhabditis elegans.”, Nature 454, 1115-1118 (2008).  PMID: 18650807 Featured in Nature Chemical Biology and SpectroscopyNOW.com
Dossey, A. T., Walse, S. S., & Edison, A. S.* “Developmental and Geographical Variation in the Chemical Defense of the Walkingstick Insect Anisomorpha buprestoides” Journal of Chemical Ecology, 34(5), 584-590 (2008). PMID: 18401661
Zhang, F.; Dossey, A. T.; Zachariah, C.; Edison, A. S., & Brüschweiler, R.* “Strategy for Automated Analysis of Dynamic Metabolic Mixtures by NMR  -  Application to an Insect Venom”, Anal Chem. 79, 7748-52. (2007). PMID: 17822309
Dossey, A. T.; Walse, S. S.; Conle, O. V.; Edison, A. S. * “Parectadial: A Novel Monoterpenoid from the Defensive Spray of Parectatosoma mocquerysi”, J Nat Prod. 70, 1335-8 (2007). PMID: 17661519 JNP 2007 Hot Article, C&E News, Beal Award
Dossey, A. T., Walse, S. S., Rocca, J. R., & Edison, A. S.* “Single Insect NMR: A New Tool to Probe Chemical Biodiversity” ACS Chemical Biology, 1 (8), 511–514 (2006). PMID: 17168538 This was a cover article and was also featured in C&E News in “News of the Week”, Sept. 25, 2006, page 15
Brey, W., Edison, A.S.*, Nast, R.E., Rocca, J., Saha, S., & Withers, R. “Design, Construction, and Validation of a 1-mm Triple-Resonance High-Temperature-Superconducting Probe for NMR” Journal of Magnetic Resonance 179, 290-3 (2006). PMID: 16423543 This was a cover article.

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