Seminar - Environmental DNA – a reservoir of functional novelty Wednesday, February 3 2016, 4pm Ecology Auditorium 201 Seminars Read more about Seminar - Environmental DNA – a reservoir of functional novelty Alan McCarthy Microbiology University of Liverpool Speaker's Website
Stephanie A. Herrlinger B.S. Molecular Genetics Graduate Student, Interdisiplinary Neuroscience PHD Program, BHSI Brain development requires the precise temporal expression and function of proteins to dictate correct neural progenitor cell (NPC) behaviors. I study the RNA-binding protein Lin28 and its capacity to drive NPC fates at the post-transcriptional level during development. NPCs have recently been discovered to be susceptible to infection and damage by the Zika virus during gestation. Our work has elucidated how the Zika virus may cause brain damage in part through disrupting neurovascular development and the blood brain barrier, as well as differences in the damage potential of different lineage isolates and Dengue virus infection in brain development. Awards & Funding: NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award (F99/K00) - 2017 - 2023 ARCS Foundation Fellowship - 2016 - 2019 NIH T32 Genetics Training Grant - 2016 - 2017 Erlanger Graduate Fellowship for Aging Research - 2015 - 2016 Graduate Student Assistantship - 2014 - 2016 Scholars of Excellence Fellowship - 2013 - 2014 Foundation Graduate Fellowship - 2013 - 2014 EGRF Award - 2013 - 2014 Selected Publications Selected Publications: Shao Q*, Herrlinger S*, Zhu YN, Yang M, Goodfellow F, Stice S, Qi XP, Brindley MA, Chen JF. The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus. Development 2017 : doi: 10.1242/dev.156752. http://dev.biologists.org/content/early/2017/10/09/dev.156752 Shao Q*, Herrlinger S*, Yang SL, Lai F, Moore JM, Brindley MA, Chen JF. Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage. Development. 2016 Oct 11. pii: dev.143768. http://dev.biologists.org/content/early/2016/10/08/dev.143768.long Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Science Advances. 2016 Sept 1; 2(9):e1601167. http://advances.sciencemag.org/content/2/9/e1601167.abstract Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA. 2016. Human glia can both induce and rescue aspects of disease phenotype in Huntington disease. Nature Communications. 2016 Jun 7;7:11758. http://www.nature.com/ncomms/2016/160607/ncomms11758/full/ncomms11758.html Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF. MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Developmental Biology. 2015 Dec 1;408(1):140-50. http://www.sciencedirect.com/science/article/pii/S0012160615301044 Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF. Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development. 2015 May 1;142(9):1616-27. http://dev.biologists.org/content/142/9/1616.short (* authors contributed equally to this work) Read more about Stephanie A. Herrlinger
Seminar - GDF11 as an Anti-Aging Factor: The Ongoing Search for the Fountain of Youth Wednesday, March 2 2016, 4pm B118 - Life Sciences Seminars Read more about Seminar - GDF11 as an Anti-Aging Factor: The Ongoing Search for the Fountain of Youth Rob Pazdro Foods and Nutrition UGA Speaker's Website
Seminar - Keep your friends close: Cooperative receptor function in shoot stem cell patterning Wednesday, February 24 2016, 4pm B118 - Life Sciences Seminars Read more about Seminar - Keep your friends close: Cooperative receptor function in shoot stem cell patterning Zack Nimchuk Biology UNC at Chapel Hill Speaker's Website
Seminar - Dominant Gene Action Accounts for Much of the Unexplained Phenotypic Variance in a Maize GWAS and Provides Insight Into Heterosis Wednesday, February 17 2016, 4pm B118 - Life Sciences Seminars Read more about Seminar - Dominant Gene Action Accounts for Much of the Unexplained Phenotypic Variance in a Maize GWAS and Provides Insight Into Heterosis Departmental Host or Contact: Jeffrey Bennetzen Patrick Schnable Plant Genomics Iowa State University Speaker's Website
Arthur Edison Professor Eminent Scholar Director PhD (1993) University of Wisconsin-Madison Grant Support - Southeast Center for Integrated Metabolomics (NIH U24DK097209), 09/01/13-08/31/18. SECIM is one of 6 NIH centers for metabolomics. Prof. Edison was the founding PI and Director at the University of Florida, and he now in PI of a UGA subcontract for NMR metabolomics. Research Interests - The Edison lab uses metabolomics and natural products chemistry to understand the chemical basis of behavior. Our primary organism for this work is Caenorhabditis elegans, a small, free-living nematode. C. elegans has been one of the best studied animals in science, with an extensive genetics, anatomy, cell, and developmental biology knowledge-base. Less is known about the role of small molecules in its development and behavior, and our studies in metabolomics can leverage the extensive understanding of this worm. We also are very interested in other nematodes, including parasitic species. Prof. Edison got his start in nematodes as a postdoc working on Ascaris suum, a large intestinal pig parasite that is very similar to a related species, Ascaris lumbricoides, which infects about 1 billion people world-wide. Selected Publications Selected Publications: “Metabolomics and Natural Products Strategies to Study Chemical Ecology in Nematodes” Arthur S. Edison*, Chaevien Clendinen, Ramadan Ajredini, Chris Beecher, Francesca Ponce, and Gregory Stupp. In Press, Invited contribution to the Journal of Integrative and Comparative Biology (2015)“An Overview of Methods for Improved Compound Identification in Metabolomics and Natural Products Using 13C.” Arthur S. Edison*, Chaevien S. Clendinen, Gregory S. Stupp+, Ramadan Ajredini, and Chris Beecher. In Press, Invited contribution to Frontiers in Plant Science (2015).Chaevien S. Clendinen, Christian Pasquel, Ramadan Ajredini, Arthur S. Edison* “13C NMR Metabolomics: INADEQUATE Network Analysis”, Anal. Chem. 87(11), 5698-5706 (2015).Menger, R. F. ‡, Clendinen, C.‡, Searcy, L. A., Edison, A. S., & Yost, R. A.*, “MALDI Mass Spectrometric Imaging of the Nematode Caenorhabditis elegans” Current Metabolomics 3, 130-137 (2015).Frelin, O., Huang, L., Hasnain, G., Jeffryes, J. G., Ziemak, M. J., Rocca, J. R., Wang, B., Rice, J., Roje, S., Yurgel, S. N., Gregory, J. F., Edison, A. S., Henry, C. S., de Crecy-Lagard, V., and Hanson, A. D.* (2015) A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis., Biochem J 466, 137-145.Clendinen, C. S., Lee-McMullen, B., Williams, C. M., Stupp, G. S., Vandenborne, K., Hahn, D. A., Walter, G. A., and Edison, A. S.* (2014) “¹³C NMR metabolomics: applications at natural abundance”, Analytical Chemistry 86, 9242-9250.Williams, C. M., Watanabe, M., Guarracino, M. R., Ferraro, M. B., Edison, A. S., Morgan, T. J., Boroujerdi, A. F., and Hahn, D. A.* (2014) “Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster”, Evolution 68, 3505-3523.Stupp, G.S., Clendinen, C., Ajredini, R., Szewc, M.A., Garrett, T., Menger, R.F., Yost, R.A., Beecher, C.* & Edison, A.S.* “Isotopic Ratio Outlier Analysis Global Metabolomics of Caenorhabditis elegans” Anal. Chem. 85, 11858-65 (2013).Ramaswamy, V., Hooker, J.W., Withers, R.S., Nast, R.E., Brey, W.W*., Edison, A.S.* “Development of a 13C-Optimized 1.5-mm High Temperature Superconducting NMR Probe” J. Magn. Reson. 235C, 58–65. (2013).Stupp, G. S., Reuss, von, S. H., Izrayelit, Y., Ajredini, R., Schroeder, F. C.*, and Edison, A. S.* (2013) “Chemical detoxification of small molecules by Caenorhabditis elegans” ACS chemical biology 8, 309–313. Featured in C&E News, Science and Technology Concentrates, Dec 3, 2012.Choe, A.&, Chuman, T.&, von Reuss, S.H.&, Dossey, A.T.&, Yim, J., Ajredini, R., Kolawa, A.A., Kaplan, F., Alborn, H.T., Teal, P.E., Schroeder, F.C., Sternberg, P.W., & Edison, A.S.* “Gender-Specific Mating Pheromones in the Nematode Panagrellus redivivus”, PNAS 109, 20949-20954 (2012).Fatma Kaplan; Hans T Alborn; Stephan H von Reuss; Ramadan Ajredini; Jared G Ali; Faruk Akyazi; Lukasz L Stelinski; Arthur S Edison; Frank C Schroeder; Peter E Teal*, "Interspecific nematode signals regulate dispersal behavior", PLoS One, 7(6), e38735, doi:10.1371/journal.pone.0038735 (2012).Srinivasan, J., von Reuss, S.H., Bose, N., Mahanti, P., Ho, M.C., O’Doherty, O.G., Edison, A.S., Sternberg, P.W.* & Schroeder, F.C.*, “A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans”, PLoS Biol 10(1): e1001237. doi:10.1371/journal.pbio.1001237 (2012).Robinette, S.L., Ajredini, R., Rasheed, H., Zeinomar, A., Schroeder F.C., Dossey, A.T., & Edison, A.S.*, “Hierarchical Alignment and Full Resolution Pattern Recognition of 2D NMR Spectra: Application to Nematode Chemical Ecology.”, Analytical Chemistry 83 (5), 1649–1657 (2011). PMID: 21314130Kaplan, F., Srinivasan, J., Mahanti, P., Ajredini, R., Durak, O., Nimalendran, R., Sternberg, P.W., Teal, P.E.A, Schroeder, F.C., Edison, A.S., and Alborn, H.T.*, “Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage”, PLoS One 6(3):e17804, (2011). PMID: 21423575Waller, J.C., Alvarez, S., Naponelli, V., Lara-Nuñez, A., Blaby, I.K., Da Silva, V., Ziemak, M.J., Vickers, T.J., Beverley, S.M., Edison, A.S., Rocca, J.R., Gregory III, J.F., de Crécy-Lagard, V., & Hanson, A.D.* “A Newly Discovered Role for Tetrahydrofolates in the Metabolismof Iron-Sulfur Clusters in All Domains of Life”, PNAS 107, 10412-72010 (2010). PMID: 20489182Kaplan, F., Badri, D. V., Zachariah, C., Ajredini, R., Sandoval, F. J., Roje, S., Levine, L. H., Zhang, F., Robinette, S. L., Alborn, H. T., Zhao, W., Stadler, M., Nimalendran, R., Dossey, A. T., Brüschweiler, R. A., Vivanco, J. M., Edison, A. S.* “Bacterial Attraction and Quorum Sensing Inhibition in Caenorhabditis elegans Exudates”, Journal of Chemical Ecology 35(8):878-92 (2009). PMID: 19649780Dossey, A. T.*, Gottardo, M., Whitaker, J., Roush, W. R., & Edison, A. S. “AlkylDimethylpyrazines in the Defensive Spray of Phyllium westwoodii: A First for Order Phasmatodea”, Journal of Chemical Ecology 35(8):861-70 (2009). PMID: 19685263. This is a cover article.Dalisay, D. S., Rogers, E. W., Edison, A. S., Molinski, T. F.* Structure Elucidation at the Nanomole-Scale. Trisoxazole macrolides and Thiazole-containing cyclic peptides from the Nudibranch Hexabranchus sanguineus, Journal of Natural Products 72, 732-8 (2009). PMID: 19254038Srinivasan, J., Kaplan, F., Ajredini, R., Zachariah, C., Alborn, H., Teal, P., Edison, A. S.*, Paul W. Sternberg, P. W.*, & Schroeder, F. C.* “A synergistic blend of small molecules differentially regulates both mating behavior and population density in Caenorhabditis elegans.”, Nature 454, 1115-1118 (2008). PMID: 18650807 Featured in Nature Chemical Biology and SpectroscopyNOW.comDossey, A. T., Walse, S. S., & Edison, A. S.* “Developmental and Geographical Variation in the Chemical Defense of the Walkingstick Insect Anisomorpha buprestoides” Journal of Chemical Ecology, 34(5), 584-590 (2008). PMID: 18401661Zhang, F.; Dossey, A. T.; Zachariah, C.; Edison, A. S., & Brüschweiler, R.* “Strategy for Automated Analysis of Dynamic Metabolic Mixtures by NMR - Application to an Insect Venom”, Anal Chem. 79, 7748-52. (2007). PMID: 17822309Dossey, A. T.; Walse, S. S.; Conle, O. V.; Edison, A. S. * “Parectadial: A Novel Monoterpenoid from the Defensive Spray of Parectatosoma mocquerysi”, J Nat Prod. 70, 1335-8 (2007). PMID: 17661519 JNP 2007 Hot Article, C&E News, Beal AwardDossey, A. T., Walse, S. S., Rocca, J. R., & Edison, A. S.* “Single Insect NMR: A New Tool to Probe Chemical Biodiversity” ACS Chemical Biology, 1 (8), 511–514 (2006). PMID: 17168538 This was a cover article and was also featured in C&E News in “News of the Week”, Sept. 25, 2006, page 15Brey, W., Edison, A.S.*, Nast, R.E., Rocca, J., Saha, S., & Withers, R. “Design, Construction, and Validation of a 1-mm Triple-Resonance High-Temperature-Superconducting Probe for NMR” Journal of Magnetic Resonance 179, 290-3 (2006). PMID: 16423543 This was a cover article. Read more about Arthur Edison
Seminar - What happens when you’re TOPLESS-diverse functions of a plant co-repressor Wednesday, September 16 2015, 3:35pm S175 Coverdell Special Information: Host - Graduate Students Seminars Read more about Seminar - What happens when you’re TOPLESS-diverse functions of a plant co-repressor Jeff Long Molecular, Cell, and Developmental Biology UCLA Speaker's Website
Seminar - Genetic approaches to study tomato fruit development Wednesday, January 27 2016, 4pm B118 - Life Sciences Seminars Read more about Seminar - Genetic approaches to study tomato fruit development Departmental Host or Contact: Chung-Jui (CJ) Tsai Esther van der Knaap Horticulture and IPBGG University of Georgia Speaker's Website
Seminar - Genetics of speciation in Mimulus Wednesday, April 6 2016, 4pm B118 - Life Sciences Seminars Read more about Seminar - Genetics of speciation in Mimulus Departmental Host or Contact: Bob Schmitz
Seminar - Smoke and hormone mirrors: the mechanism and evolution of karrikin and strigolactone signaling Wednesday, March 16 2016, 4pm B118 - Life Sciences Seminars Read more about Seminar - Smoke and hormone mirrors: the mechanism and evolution of karrikin and strigolactone signaling Departmental Host or Contact: Bob Schmitz