Developmental Biology

Developmental Biology Personnel

Neural progenitor cells (NPCs), neural development, and neural degeneration

Stem cell biology, somatic cell reprogramming and vertebrate developmental genetics. Defining the key genes and regulatory elements that regulate fetal thymus development in mice; genome editing and epigenome editing (via CRISPR).

Mammalian developmental genetics: mechanisms that control tissue patterns during mammalian embryonic development; signaling pathways that function in cell fate specification; identification of novel regulators of Hedgehog signaling pathways in central nervous system

The Goll laboratory is interested in epigenetics and chromatin regulation in the context of development and disease. We exploit a combination of genetic, genomic, molecular and cell biology based approaches to ask these questions using zebrafish as our primary model.

Developmental genetics of vertebrate organogenesis: life history of the thymus (responsible for the generation of T cells); diverse aspects of biology of organ controlled by cellular dynamics, regulatory networks, and physiological processes; organ homeostasis, aging, and regeneration

Developmental regulation and evolution of vertebrate morphology: how the expression of limb genes is regulated and to what degree changes in the regulation of limb genes contributes to evolution of divergent limb morphologies; identification of regulatory elements that control expression of limb

Extremophile biology, biotechnology, and bioenergy: conversion of biomass from crop plants into biofuels; identification, characterization, and manipulation of microorganisms and biocatalysts for biomass conversion; access to new pathways for biomass conversion; ability to genetically manipulate