Meagher Laboratory

Richard Brian Meagher
Distinguished Research Professor
Department of Genetics
Life Science Building
University of Georgia
Athens, GA 30602

Phone: 706-542-1410

Fax: 706-542-1387

E-mail: meagher@uga.edu

EDUCATION

University of Illinois, Champaign, IL B.S. 1969 Biology

Yale University, New Haven, CT M.Phil. 1971 Biology and Bacterial Physiology

Yale University, New Haven, CT Ph.D. 1973 Biology and Enzymology

ACADEMIC POSITIONS & AWARDS

1969 Graduated with "Distinction in Honors Biology" from the University of Illinois working on the genomes of plant double stranded RNA viruses.

1969 to 1973 Graduate student with L. Nicholas Ornston at Yale University, Protein chemistsry of enzymes in aromatic catabolism

1973 to 1974 Postdoctoral Fellow in the laboratory of Dr. Bruce Ames at University of California, Berkeley, Carcinogenesis as mutagens

1974 to 1976 Postdoctoral Scholar at the University of California, in the laboratories of Herbert Boyer and Howard Goodman, San Francisco, First cloning and characterization of plant DNA expression in bacteria

1976 to 1980 Assistant Professor of Microbiology & Botany, Program in Genetics, University of GA

1980 to 1982 Assistant Professor of Molecular and Population Genetics, University of Georgia

1983 to 1988 Associate Professor of Genetics, University of Georgia

1987 University of Georgia Creative Research Award

1987 to 1994 Co-Founder and Acting Director of the University's "Molecular Genetics Instrumentation Facilty"

1989 to 1995 Co-Founder and Co-Director of the University's "Research Computation Resources"

1988 to 2006 Professor of Genetics, University of Georgia

1995 to 1998 Genetics Department Head, University of Georgia

2001 University of Georgia Research Foundation's Lamar Dodd Award for Scientific Research

2004 University of Georgia Research Foundation's Inventor's Award

2006 to present. Distinguished Research Professor, Genetics Department, University of Georgia

 

PUBLICATIONS - Full-Length Research Articles (see URL links to pdf files for some recent publications in the laboratory publication list)

 

148. Deal, R.B., Topp, C.N., McKinney, E.C., and Meagher, R.B. (2007) Repression of flowering in Arabidopsis requires activation of FLOWERING LOCUS C expression by the histone variant H2A.Z. Plant Cell 19, 74-83.

 

147. Meagher, R.B., Kandasamy, M.K., Deal, R.B., and McKinney, E.C. (2007) Actin-related proteins in chromatin-level control of the cell cycle and developmental transitions. Trends Cell Biol 17, 325-32.

 

146. Kandasamy, M.K., Burgos-Rivera, B., McKinney, E.C., Ruzicka, D., and Meagher, R.B. (2007) Class-specific interactions of profilin and ADF isovariants with actin in the regulation of plant development. Plant Cell. In Press.

 

145. Ruzicka, D., Kandasamy, M.K., McKinney, E.C., Bursos-Rivera, B., and Meagher, R.B. (2007) The ancient subclasses of Arabidopsis ACTIN DEPOLYMERIZING FACTOR genes exhibit novel and differential expression. Plant J. In Press.

 

144. Lyyra, S., Meagher, R.B., Kim, T., Heaton, A., Montello, P., Balish, R.S., and Merkle, S.A. (2007) Coupling two mercury resistance genes in Eastern cottonwood enhances the processing of organomercury. Plant Biotechnol J 5, 254-62.

 

143. Meagher, R.B., Smith, A.P., Pischke, M., Kim, T., Dhankher, O.P., and Heaton, A.C.P. (2007) Multigene strategies for engineering the phytoremediation of mercury and arsenic. In: Biotechnology and Sustainable Agriculture and Beyond. Editor: Xu, Z. Bejing, Springer. In Press.

 

142. Che, D.S., Meagher, R.B., Kim, R., Heaton, A.C.P., Lima, A., Rugh, C.L., and Merkle, S.A. (2006) Expression of organomercury lyase in Eastern cottonwood enhances organic mercury resistance. In Vitro Cell. Dev. Biol. 42, 228-234.

141. Dhankher, O.P., Rosen, B.P., McKinney, E.C., and Meagher, R.B. (2006) Hyperaccumulation of arsenic in the shoots of Arabidopsis silenced for arsenate reductase (ACR2). Proc Natl Acad Sci U S A 103, 5413-5418.

 

140. Li, Y., Dankher, O.P., Carreira, L., Smith, A.P., and Meagher, R.B. (2006a) The shoot-specific expression of gamma-glutamylcysteine synthetase directs the long-distance transport of thiol-peptides to roots conferring tolerance to mercury and arsenic. Plant Physiol 141, 288-98.

 

139. Li, Y., Heaton, A.C.P., Carareira, L., and Meagher, R.B.(2006b). Enhanced tolerance to and accumulation of mercury, but not arsenic, in plants overexpressing two enzymes required for thiol peptide synthesis. Physiol Plantarum 128, 48-57.

 

138. Meagher, R.B.(2006a). Plants tackle explosive contamination. Nat Biotechnol 24, 161-3.

 

137. Meagher, R.B., Kim, T., Smith, A.P., and Heaton, A.C.P.(2006). Designing plants for the remediation mercury- and arsenic-polluted soils and water. In: Designing Industrial Crops, In Press, T. McKeon, and L. Jiann-Tsyh, eds American Chemical Society Books), pp. 272.

 

136. Pawloski, L.C., Kandasamy, M.K., and Meagher, R.B.(2006). The late pollen actins are essential for normal male and female development in Arabidopsis. Plant Mol Biol 62, 881-96.


135. Deal, R.B., Kandasamy, M.K., McKinney, E.C. and Meagher, R.B. 2005. The Nuclear Actin-Related Protein ARP6 Is a Pleiotropic Developmental Regulator Required for the Maintenance of FLOWERING LOCUS C Expression and Repression of Flowering in Arabidopsis. Plant Cell 17: 2633-2646.


134. Heaton, A., Rugh, C. and Meagher, R. 2005. Physiological Responses of Transgenic merA-Tobacco (Nicotiana tabacum) to Foliar and Root Mercury Exposure. Water, Air, Soil Pollu. 161, 137-155.


133. Kandasamy, M.K., Deal, R.B., McKinney, E.C. and Meagher, R.B. 2005a. Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has multiple effects on plant development, including early flowering and delayed floral senescence. Plant J 41: 845-58.


132. Kandasamy, M.K., McKinney, E.C., Deal, R.B. and Meagher, R.B. 2005b. ARP7 is an essential actin-related protein required for embryo development and its knockdown affects plant architecture and flower senescence in Arabidopsis. Plant Physiol 138: 2019-2032.


131. Kim, T., Balish, R.S., Heaton, A.C.P., McKinney, E.C. and Meagher, R.B. 2005. Engineering a Root-Specific, Repressor-Operator Gene Complex. Plant Biotech 3: 571-582.

 

130. Li, Y., Dhankher, O., Carreira, L., Balish, R. and Meagher, R. 2005. Engineered overexpression of g-glutamylcysteine synthetase in plants confers high level arsenic and mercury tolerance. Env Tox & Chem 24: 36-45.


129. Li, Y., Dhankher, O., Carreira, L., Balish, R. and Meagher, R. 2005. Arsenic and mercury tolerance and cadmium sensitivit yin Arabidopsis plants expressing bacterial gamma-glutamylcysteine synthetase. Env Tox & Chem 24: 1376-1386.


128. McCaig, B.M., Meagher, R.B. and Dean, J.F.D. 2005. Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana. Planta In Press:


127. Meagher, R.B., Deal, R.B., Kandasamy, M.K. and McKinney, E.C. 2005b. Nuclear actin-related proteins as epigenetic regulators of development. Plant Physiol 139: 1576-85.


126. Meagher, R.B. and Heaton, A.C. 2005. Strategies for the engineered phytoremediation of toxic element pollution: mercury and arsenic. J Ind Microbiol Biotechnol 32: 502-13.


125. Meagher, R.B., Kim, T., Smith, A.P. and Heaton, A.C.P. 2005d. Designing plants for the remediation mercury- and arsenic-polluted soils and water. In: McKeon, T., (ed) Designing Industrial Crops, pp. ACS Books


124. Pawloski, L.C., Deal, R.B., McKinney, E.C., Burgos-Rivera, B. and Meagher, R.B. 2005. Inverted repeat PCR for the rapid assembly of constructs to induce RNA interference. Plant Cell Physiol 46: 1872-8.


123. Zimeri, A.M., Dhankher, O.P., McCaig, B. and Meagher, R.B. 2005. The plant MT1 metallothioneins are stabilized by binding cadmiums and are required for cadmium tolerance and accumulation. Plant Mol Biol 58: 839-55.


122. Kandasamy, M.K., Deal, R.B., McKinney, E.C. and Meagher, R.B. 2004. Plant actin-related proteins. Trends Plant Sci 9: 196-202.


121. Li, Y., Dhankher, O., Carreira, L., Lee, D., Chen, A., Schroeder, J., Balish, R. and Meagher, R. 2004. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium sensitivity. Plant & Cell Physiol. 45: 1787-1797.


120. Gilliland, L.U., Pawloski, L.C., Kandasamy, M.K. and Meagher, R.B. 2003. Arabidopsis actin gene ACT7 plays an essential role in germination and root growth. Plant J 33: 319-28.


119. Liu, R., Ferrenberg, A.M., Gilliland, L.U. and Meagher, R.B. 2003. Detection of deleterious genotypes in multigenerational studies. III. Estimation of selection components in highly selfing populations. Genetical Research 82: 41-53.


118. Meagher, R.B. and Fechheimer, M. 2003. The Cytoskeletal Proteome of Arabidopsis. In: Meyerowitz, E. and Somerville, C., (ed) Arabidopsis, pp. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.


117. Vitale, A., Wu, R.J., Cheng, Z. and Meagher, R.B. 2003. Multiple conserved 5' elements are required for high-level pollen expression of the Arabidopsis reproductive actin ACT1. Plant Mol Biol 52: 1135-51.

116. Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. 2003. Cell cycle dependent association of Arabidopsis actin-related proteins AtARP4 and AtARP7 with the nucleus. Plant Journal 33:939-948.


115. Bizily, S., Kim, T., Kandasamy, M. K., and Meagher, R. B. (2003). Subcellular targeting of methylmercury lyase enhances its specific activity for organic mercury detoxification in plants. Plant Physiol 131, 463-471.


114. Che, D. S., Meagher, R. B., Heaton, A. C. P., Lima, A., and Merkle, S. A. (2003). Expression of mercuric ion reductase in eastern cottonwood confers mercuric ion reduction and resistance. Plant Biotech In Press.


113. Dhankher, O. P., Rosen, B. P., Fuhrman, M., and Meagher, R. B. (2003). Increased cadmium tolerance and accumulation by plants expressing bacterial arsenate reductase. New Phytologist In Press.


112. Heaton, A., Rugh, C., Kim, R., Wang, J., and Meagher, R. (2003). Toward detoxifying mercury-polluted aquatic sediments using rice genetically-engineered for mercury resistance. Env Tox & Chem In press.


111. Cobbett, C., and Meagher, R. (2003). Phytoremediation and the Arabidopsis proteome. In Arabidopsis, E. Meyerowitz, and C. Somerville, eds. (Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press), pp. In press


110. Dhankher, O. P., Li, Y., Rosen, B. P., Shi, J., Salt, D., Senecoff, J. F., Sashti, N. A., and Meagher, R. B. (2002). Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression. Nat Biotechnol 20, 1140-1145.


109. Gilliland, L. U., Kandasamy, M. K., Pawloski, L. C., and Meagher, R. B. (2002). Both vegetative and reproductive actin isovariants complement the stunted root hair phenotype of the Arabidopsis act2-1 mutation. Plant Physiol 130, 2199-2209.


108. Kandasamy, M. K., McKinney, E. C., and Meagher, R. B. (2002a). Functional non-equivalency of actin isovariants in Arabidopsis. Mol Biol Cell 13, 251-261.


107. Kandasamy, M. K., McKinney, E. C., and Meagher, R. B. (2002b). Plant profilin isovariants are distinctly regulated in vegetative and reproductive tissues. Cell Motil Cytoskeleton 52, 22-32.


106. McKinney, E. C., Kandasamy, M. K., and Meagher, R. B. (2002). Arabidopsis contains ancient classes of differentially expressed actin- related protein genes. Plant Physiol 128, 997-1007.


105. Meagher, R. B. (2002). Post-genomics networking of biotechnology for interpreting gene function. Curr Opin Plant Biol, 135-140.


104. Meagher, R. B., and Fechheimer, M. (2002). The Cytoskeletal Proteome of Arabidopsis. In Arabidopsis, E. Meyerowitz, and C. Somerville, eds. (invited publication).


103. Kandasamy, M. K., Gilliland, L. U., McKinney, E. C., and Meagher, R. B. (2001). One plant actin isovariant, ACT7, is induced by auxin and required for normal callus formation. Plant Cell 13, 1541-1554.


102. Lawrence, C. J., Morris, N. R., Meagher, R. B., and Dawe, R. K. (2001). Dyneins have run their course in plant lineage. Traffic 2, 362-363.


101. Li, Y., Kandasamy, M. K., and Meagher, R. B. (2001). Rapid isolation of monoclonal antibodies: monitoring enzymes in the phytochelatin synthesis pathway. Plant Physiol 127, 711-719.


100. McKinney, E. C., Kandasamy, M. K., and Meagher, R. B. (2001). Small changes in the regulation of one Arabidopsis profilin isovariant, prf1, alter seedling development. Plant Cell 13, 1179-1191.


99. Meagher, R. B. (2001). Pink water, green plants, and pink elephants. Nat Biotechnol 19, 1120-1121.


98. Bizily, S. P., Rugh, C. L., and Meagher, R. B. (2000b). Phytodetoxification of hazardous organomercurials by genetically engineered plants. Nat Biotechnol 18, 213-217.


97. Meagher, R. B. (2000). Phytoremediation of toxic elemental and organic pollutants. Curr Opin Plant Biol 3, 153-162.


96. Meagher, R. B., McKinney, E. C., and Kandasamy, M. K. (2000a). The significance of diversity in the plant actin gene family: Studies in Arabidopsis. In Actin: A dynamic framework for multiple plant cell functions, C. J. Staiger, F. Baluska, D. Volkmann, and P. Barlow, eds. (Dordrecht, The Netherlands, Klewer Academic Publishers), pp. 3-27.


95. Meagher, R. B., Rugh, C. L., Kandasamy, M. K., Gragson, G., and Wang, N. J. (2000b). Engineered phytoremediation of mercury pollution in soil and water using bacterial genes. In Phytoremediation of Contaminated Soil and Water, N. Terry, and G. Banuelos, eds. (Boca Raton, Lewis Publishers), pp. 203-221.


94. Palanivelu, R., Belostotsky, D. A., and Meagher, R. B. (2000a). Arabidopsis thaliana poly (A) binding protein 2 (PAB2) functions in yeast translational and mRNA decay processes. Plant J 22, 187-198.


93. Palanivelu, R., Belostotsky, D. A., and Meagher, R. B. (2000b). Conserved expression of Arabidopsis thaliana poly (A) binding protein 2 (PAB2) in distinct vegetative and reproductive tissues. Plant J 22, 199-210.


92. Rugh, C. L., Bizily, S. P., and Meagher, R. B. (2000). Phytoremediation of environmental mercury pollution. In Phytoremediation of toxic metals: Using plants to clean-up the environment, B. Ensley, and I. Raskin, eds. (New York, Wiley and Sons), pp. 151-169.


91. Bizily, S., Rugh, C. L., Summers, A. O., and Meagher, R. B. (1999). Phytoremediation of methylmercury pollution: merB expression in Arabidopsis thaliana confers resistance to organomercurials. Proc Natl Acad Sci USA 96, 6808-6813.


90. Kandasamy, M. K., and Meagher, R. B. (1999). Actin-organelle interaction: association with chloroplast in Arabidopsis leaf mesophyll cells. Cell Motil Cytoskeleton 44, 110-118.


89. Kandasamy, M. K., McKinney, E. C., and Meagher, R. B. (1999). The late pollen-specific actins in angiosperms. Plant J 18, 681-691.
88. Meagher, R. B., McKinney, E. C., and Vitale, A. V. (1999a). The evolution of new structures: clues from plant cytoskeletal genes. Trends Genet 15, 278-284.


87. Meagher, R. B., McKinney, E. C., and Kandasamy, M. K. (1999b). Isovariant dynamics expand and buffer the responses of complex systems: the diverse plant actin gene family. Plant Cell 11, 995-1006.


86. Asmussen, M. A., Gilliland, L. U., and Meagher, R. B. (1998). Detection of deleterious genotypes in multigenerational studies. II. Theoretical and experimental dynamics with selfing and selection. Genetics 149, 727-737.


85. Gilliland, L. U., McKinney, E. C., Asmussen, M. A., and Meagher, R. B. (1998). Detection of deleterious genotypes in multigenerational studies. I. Disruptions in individual Arabidopsis actin genes. Genetics 149, 717-725.


84. Heaton, A. C. P., Rugh, C. L., Wang, N.-J., and Meagher, R. B. (1998). Phytoremediation of mercury and methylmercury polluted soils using genetically engineered plants. J Soil Contam 7, 497-509.


83. McKinney, E., and Meagher, R. (1998). Members of the Arabidopsis actin gene family are widely dispersed in the genome. Genetics 149, 663-675.


81. Rugh, C. L., Senecoff, J. F., Meagher, R. B., and Merkle, S. A. (1998a). Development of transgenic yellow poplar for mercury phytoremediation. Nat Biotechnol 16, 925-928.


80. Rugh, C. L., Gragson, G. M., and Meagher, R. B. (1998b). Toxic mercury reduction and remediation using transgenic plants with a modified bacterial gene. Hort Sci 33, 12-15.


79. Huang, S., An, Y.-Q., McDowell, J. M., McKinney, E. C., and Meagher, R. B. (1997). The Arabidopsis ACT11 actin gene is strongly expressed in tissues of the emerging inflorescence, pollen and developing ovules. Plant Mol Biol 33, 125-139.


77. An, Y.-Q., Huang, S., McDowell, J. M., McKinney, E. C., and Meagher, R. B. (1996a). Conserved expression of the Arabidopsis ACT1 and ACT3 actin subclass in organ primordia and mature pollen. Plant Cell 8, 15-30.


76. An, Y.-Q., McDowell, J. M., Huang, S., McKinney, E. C., Chambliss, S., and Meagher, R. B. (1996b). Strong, constitutive expression of the Arabidopsis ACT2/ACT8 actin subclass in vegetative tissues. Plant J 10, 107-121.


75. Belostotsky, D. A., and Meagher, R. B. (1996). A pollen-, ovule-, and early embryo-specific poly(A) binding protein from Arabidopsis complements essential functions in yeast. Plant Cell 8, 1261-1275.

74. Huang, S., An, Y.-Q., McDowell, J. M., McKinney, E. C., and Meagher, R. B. (1996c). The Arabidopsis ACT4/ACT12 actin gene subclass is strongly expressed in post-mitotic pollen. Plant J 10, 189-202.

73. Huang, S., J.M., M., Weise, M. J., and Meagher, R. B. (1996b). The Arabidopsis profilin gene family: Evidence for an ancient split between constitutive and pollen-specific profilin genes. Plant Physiol 111, 115-126.

72. McDowell, J. M., An, Y.-Q., McKinney, E. C., Huang, S., and Meagher, R. B. (1996a). The Arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli. Plant Physiol 111, 699-711.

71. McDowell, J. M., Huang, S., McKinney, E. C., An, Y. Q., and Meagher, R. B. (1996b). Structure and evolution of the actin gene family in Arabidopsis thaliana. Genetics 142, 587-602.


69. Pellock, B. J., Albert, L., Meagher, R. B., Weise, M. J., and Miller, L. K. (1996). Sequence, function and phylogenetic analysis of an ascovirus DNA polymerase gene. Virology 216, 146-157.


68. Rugh, C. L., Wilde, D., Stack, N. M., Thompson, D. M., Summers, A. O., and Meagher, R. B. (1996). Mercuric ion reduction and resistance in transgenic Arabidopsis thaliana plants expressing a modified bacterial merA gene. Proc Natl Acad Sci USA 93, 3182-3187.

67. Senecoff, J. F., McKinney, E. C., and Meagher, R. B. (1996). DeNovo Purine synthesis in Arabidopsis thaliana II. The Pur 7 gene encoding 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole synthetase is expressed in rapidly dividing tissues. Plant Physiol 112, 905-917.

66. Y-Q., A., Huang, S., McDowell, J. M., McKinney, E. C., and Meagher, R. B. (1996a). Conserved expression of the Arabidopsis ACT1 and ACT 3 actin subclass in organ primordia and mature pollen. The Plant Cell 8, 15-30.


65. Grote, M., Swoboda, I., Meagher, R. B., and Valenta, R. (1995). Localization of profilin- and actin-like immunoreactivity in in vitro-germinated tobacco pollen tubes by electron microscopy after special water-free fixation techniques. Sex Plant Reprod 8, 180-186.


64. McKinney, E. C., Ali, N., Traut, A., Feldmann, K. A., Belostotsky, D. A., McDowell, J. M., and Meagher, R. B. (1995). Sequence-based identification of T-DNA insertion mutations in Arabidopsis: actin mutants act2-1 and act4-1. Plant J 8, 613-622.


63. Meagher, R. B. (1995). The impact of historical contingency on gene phylogeny: Plant actin diversity. In Evolutionary Biology, M. Hecht, R. MacIntyre, and M. Clegg, eds. (NY, Plenum Press), pp. 195-215.


62. Tanzer, M. M., and Meagher, R. B. (1995). Degradation of the Soybean ribulose-1,5-bisphosphate carboxylase small-subunit mRNA, SRS4, initiates with endonucleolytic cleavage. Mol Cell Biol 15, 6641-6652.


61. Fletcher, L. D., McDowell, J. M., Tidwell, R. R., Meagher, R. R., and Dykstra, C. C. (1994). Structure, expression and phylogenetic analysis of the gene encoding actin I in Pneumocystis carinii. Genetics 137, 1-8.


60. Meagher, R. B., and Williamson, R. E. (1994). The Plant Cytoskeleton. In Arabidopsis, E. Meyerowitz, and C. Somerville, eds. (Cold Spring Harbor, Cold Spring Harbor Laboratory Press), pp. 1049-1084.


59. Tanzer, M. M., and Meagher, R. B. (1994). Faithful degradation of soybean rbcS mRNA in vitro. Mol Cell Biol 14, 2640-2650.


58. Belostotsky, D., and Meagher, R. B. (1993). Differential organ-specific expression of three poly(A) binding protein genes from Arabidopsis thaliana. Proc Natl Acad Sci USA 90, 6686-6690.


57. Senecoff, J., and Meagher, R. B. (1993a). Isolating the Arabidopsis thaliana genes for de novo purine synthesis by suppression of Escherichia coli mutants: 5'-Phosphoribosyl-5-aminoimidazole synthetase. Plant Physiol 102, 387-399.


55. Senecoff, J. F., and Meagher, R. B. (1993c). In vivo analysis of plant 18S rRNA structure: Evolution of plant 18S rRNA. In Methods in Enzymology, E. A. Zimmer, T. J. White, R. L. Cann, and A. C. Wilson, eds. (San Diego, CA, Academic Press, Inc.), pp. 357-372.


54. Valenta, R., Ferreira, F., Grote, M., Swoboda, I., Vrtala, S., Duchene, M., Deviller, P., Meagher, R., McKinney, E., Heberle-Bores, E., et al. (1993). Identification of profilin as an actin binding protein in higher plants. J Biol Chem 268, 22777-22781.


53. Senecoff, J. F., and Meagher, R. B. (1992). In vivo analysis of plant RNA structure: Soybean 18S ribosomal and ribulose-1,5-bisphospahte carboxylase small subunit RNAs. Plant Mol Biol 18, 219-234.


52. Thompson, D. M., Tanzer, M. M., and Meagher, R. B. (1992). Degradation products of the mRNA encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean and transgenic petunia. Plant Cell 4, 47-58.


51. Wilde, H. D., Meagher, R. B., and Merkle, S. A. (1992a). Expression of foreign genes in transgenic yellow poplar plants. Plant Physiology 98, 114-120.


50. Wilde, H. D., Meagher, R. B., and Merkle, S. A. (1992b). Expression of foreign genes in transgenic yellow-poplar plants. Plant Physiol 98, 114-120.


49. Meagher, R. B. (1991). Divergence and differential expression of actin gene families in higher plants. Int Rev Cytol 125, 139-163.


48. Condit, C. M., McLean, B. G., and Meagher, R. B. (1990). Characterization of the expression of the petunia glycine-rich protein-1 gene product. Plant Physiology 93, 596-602.


47. McLean, B. G., Huang, S., McKinney, E. C., and Meagher, R. B. (1990a). Plants contain highly divergent actin isovariants. Cell Motil Cytoskeleton 17, 276-290.


46. McLean, B. G., Eubanks, S., and Meagher, R. B. (1990b). Tissue specific expression of divergent actins in soybean root. Plant Cell 2, 335-344.


45. McLean, M., Gerats, A. G. M., Baird, W. V., and Meagher, R. B. (1990c). Six actin gene subfamilies map to five chromosomes of Petunia hybrida. J Heredity 81, 341-346.


44. Meagher, R. B., and McLean, B. G. (1990). Diversity of plant actins. Cell Motil Cytoskeleton 16, 164-166.


43. Meagher, R. B., Ngai, K. L., and Ornston, L. N. (1990a). Muconate cycloisomerase. In Methods in Enzymology, M. E. Lidstrom, ed. (Academic Press, Inc.), pp. 126-130.


42. Meagher, R. B., Ngai, K. L., and Ornston, L. N. (1990b). Muconolactone Isomerase. In Hydrocarbons and Methyltrophy, M. E. Lindstrom, ed. (New York, Academic Press, Inc.), pp. 130-133.


41. Pearson, L., and Meagher, R. B. (1990). Diverse soybean actin transcripts contain a large intron in the 5' untranslated leader: Structural similarity to vertebrate muscle actin genes. Plant Mol Biol 14, 513-526.


40. Shirley, B. W., Ham, D. P., Senecoff, J. F., Berry-Lowe, S. L., Zurfluh, L. L., Shah, D. M., and Meagher, R. B. (1990). Comparison of the expression of two highly homologous members of the soybean ribulose-1,5- bisphospate carboxylase small subunit gene family. Plant Mol Biol 14, 909-925.


39. Shirley, B. W., and Meagher, R. B. (1990). A potential role for RNA turnover in the light regulation of plant gene expression: ribulose-1,5-bisphosphate carboxylase small subunit in soybean. Nuc Acids Res 18, 3377-3385.


38. Thompson, D. M., and Meagher, R. B. (1990). Transcriptional and post-transcriptional processes regulate expression of RNA encoding the small subunit of ribulose-1,5-biphosphate carboxylase differently in petunia and in soybean. Nucleic Acids Res 18, 3621-3629.


37. Meagher, R. B., Berry-Lowe, S., and Rice, K. (1989). Molecular evolution of the small subunit of ribulose bisphosphate carboxylase: Nucleotide substitution and gene conversion. Genetics 123, 845-863.


36. McLean, M. D., Baird, W. V., Gerats, A. G. M., and Meagher, R. B. (1988). Determination of copy number and linkage relationships among five actin gene subfamilies in Petunia hybrida. Plant Mol Biol 11, 663-672.


35. Meagher, R. B., McLean, M. D., and Arnold, J. (1988). Recombination within a subclass of restriction fragment length polymoprhisms may help link classical and molecular genetics. Genetics 120, 809-818.


34. Baird, W. V., and Meagher, R. B. (1987). A complex gene superfamily encodes actin in petunia. EMBO J 6, 3223-3231.


33. Condit, C. M., and Meagher, R. B. (1987). Expression of a Gene Encoding a Glycine-Rich Protein in Petunia. Mol Cell Biol 7, 4273-4279.


32. Shirley, B. W., Berry-Lowe, S. L., Rogers, S. G., Flick, J. S., Horsch, R., Fraley, R. T., and Meagher, R. B. (1987). 5' proximal sequences of a soybean ribulose-1,5-bisphosphate carboxylase small subunit gene direct light and phytochrome controlled transcription. Nucleic Acids Res 15, 6501-6514.


31. Condit, C., and Meagher, R. B. (1986). A gene encoding a novel glycine-rich structural protein of petunia. Nature 323, 178-181.


30. Grandbastien, M. A., Berry-Lowe, S., Shirley, B. W., and Meagher, R. B. (1986). Two soybean ribulose-1,5-bisphosphate carboxylase small subunit genes share extensive homology even in distant flanking sequences. Plant Mol Biol 7, 451-465.


29. Hightower, R. C., and Meagher, R. B. (1986). The molecular evolution of actin. Genetics 114, 315-332.


28. Berry-Lowe, S., and Meagher, R. B. (1985). Transcriptional regulation of a gene tissue encoding the small subunit of ribulose-1,5-biosphosphate carboxylase in soybean is linked to the phytochrome response. Mol Cell Biol 5, 1910-1917.


27. Eckenrode, V. K., Arnold, J., and Meagher, R. B. (1985). Comparison of the nucleotide sequence of soybean 18S rRNA with the sequence of other small subunit rRNAs. J Mol Evol 21, 259-269.


26. Hightower, R. C., and Meagher, R. B. (1985). Divergence and differential expression of soybean actin genes. EMBO J 4, 1-8.


25. Condit, C., Hagen, T. J., McKnight, T. D., and Meagher, R. B. (1983). Characterization and preliminary mapping of cauliflower mosaic virus transcripts. Gene 25, 101-108.


24. Condit, C., and Meagher, R. B. (1983). Multiple, discrete 35S transcripts of cauliflower mosaic virus. J Mol Appl Gen 2, 301-314.


23. Meagher, R. B., and Hightower, R. C. (1983). Plant Actin is Encoded by Diverse Multigene Families. 171-189.


22. Shah, D. M., Hightower, R. C., and Meagher, R. B. (1983). Genes encoding actin in higher plants: Intron positions are highly conserved but the coding sequences are not. J Mol Appl Gen 2, 111-126.


21. Berry-Lowe, S. L., McKnight, T. D., Shah, D. M., and Meagher, R. B. (1982). The nucleotide sequence, expression, and evolution of one member of a multigene family encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean. J Mol Appl Genet 1, 483-498.


20. Hagen, T., Taylor, D. B., and Meagher, R. B. (1982). Rocket immunoelectrophoresis assay for cauliflowr mosaic virus. Phytopathology 72, 239-242.


19. Shah, D. M., Hightower, R. C., and Meagher, R. B. (1982). Complete nucleotide sequence of a soybean actin gene. Proc Natl Acad Sci USA 79, 1022-1026.


18. Bohlander, F. A., Summers, A. O., and Meagher, R. B. (1981). Cloning a promoter that puts the expression of tetracycline resistance under the control of the regulatory elements of the mer operon. Gene 15, 395-403.


17. McKnight, T. D., and Meagher, R. B. (1981). Isolation and mapping of small cauliflower mosaic virus DNA fragments active as promoters in E. coli. J Virol 37, 673-682.


16. Nagao, R. T., Shah, D. M., Eckenrode, V. K., and Meagher, R. B. (1981). Multigene family of actin-related sequences isolated from soybean genomic library. DNA 1, 1-9.


15. Carreira, L. H., Carlton, B. C., Bobbio, S. M., Nagao, R. T., and Meagher, R. B. (1980). Construction and application of a modified gene machine: A circular concentrating preparative gel electrophoresis device employing discontinuous elution. Anal Biochem 106, 455-468.


14. Makula, R. A., and Meagher, R. B. (1980). A new restriction endonuclease from the anaerobic bacterium, desulfovibrio desulfuricans. Nuc Acids Res 8, 3125-3131.


12. Friedrich, H., Hemleben, V., and Meagher, R. B. (1979). Purification and restriction endonuclease mapping of soybean 18 S and 25 S Ribosomal RNA genes. Planta 146, 467-473.


11. Meagher, R. B. (1977a). The development of a molecular cloning system in higher plants. Basic Life Sci 9, 129-158.

From the Herbert Boyer laboratory at UCSF


10. Meagher, R. B., Tait, R. C., Betlach, M., and Boyer, H. W. (1977a). Protein expression in E. coli minicells by recombinant plasmids. Cell 10, 521-536.


9. Meagher, R. B. (1977b). Purification and partial amino acid sequence of the cyanogen bromide fragments of muconolactone isomerase from Pseudomonas putida. Biochem Biophys Acia 494, 33-47.


8. Meagher, R. B., Shepherd, R. J., and Boyer, H. W. (1977b). The structure of cauliflower mosaic virus. I. A restriction endonuclease map of cauliflower mosaic virus DNA. Virology 80, 362-375.

From the L.N. Ornston laboratory at Yale


6. Meagher, R. B. (1975). Rapid manual sequencing of multiple peptide samples in a nitrogen chamber. Anal Biochem 67, 404-412.


5. Patel, R. N., Meagher, R. B., and Ornston, L. N. (1974). Relationships among enzymes of the b-ketoadipate pathway. IV. Muconolactone isomerase from Acinetobacter calcoaceticus and Pseudomonas putida. J Biol Chem 249, 7410-7419.


4. Meagher, R. B., and Ornston, L. N. (1973). Relationships among enzymes of the beta-ketoadipate pathway. I. Properties of cis,cis-muconate-lactonizing enzyme and muconolactone isomerase from Pseudomonas putida. Biochemistry 12, 3523-3530.


3. Parke, D., Meagher, R. B., and Ornston, L. N. (1973). Relationships among enzymes of the beta-ketoadipate pathway. 3. Properties of crystalline gamma-carboxymuconolactone decarboxylase from Pseudomonas putida. Biochemistry 12, 3537-3542.


2. Patel, R. N., Meagher, R. B., and Ornston, L. N. (1973). Relationships among enzymes of the beta-ketoadipate pathway. II. Properties of crystalline beta-carboxy-cis,cis-muconate-lactonizing enzyme from Pseudomonas putida. Biochemistry 12, 3531-3537.


1. Meagher, R. B., McCorkle, G. M., Ornston, M. K., and Ornston, L. N. (1972). Inducible uptake system for b-carboxy-cis, cis-muconate in permeability mutant of Pseudomonas putida. J Bacteriol 111, 465-473.

 

PATENTS

U.S. PATENT APPLICATION SERIAL NO. 10/1079,130 issued August, 2006 for “Rapid Production of Monoclonal Antibodies”.


U.S. PATENT NO. 5,965,796 issued October 12, 1999 for "Metal Resistance Sequences and Transgenic Plants" on the phytodetoxification of organo-metalic toxins in the environment.


U.S. PATENT NO. 5,668,294 issued September 16, 1997 for "Metal Resistance Sequences in Transgenic Plants" on phytoremediation by metal ion reduction.

 

CURRENT GRANT SUPPORT
NIH - Meagher, $1,360,000 D&I Jan., 2004- to Dec., 2007, "Differential Expression of the Diverse Plant Actins"

NIH - Meagher, $1,504.500 D&I Jan., 2008 to Dec., 2011, "Differential Expression of the Diverse Plant Actins"
DOE- Meagher, $750,000 D&I Sept., 2005 to Aug. 30, 2008, "Phytoremediation of Ionic and Methyl Mercury Pollution"
ABEOME Corporation, Meagher, $44,000 D&I. 2007 to 2008, "Isotype Switching and the Rapid Production of Monoclonal Antibodies"
INSECTIGEN Corporation, Meagher, $99,000 D&I, 2007 to 2008, "Transgenic co-expression of genes for insect pathogen resistance in plants"