Meagher Laboratory

 

Elizabeth C. McKinney
Research Professional III
Department of Genetics
Life Science Building
University of Georgia
Athens, GA 30602

Phone: 706-542-1410

Fax: 706-542-1387

E-mail: emckiney@uga.edu

EDUCATION

1986 Texas A&M University, College Station Texas- M.S. in Biology

1984 Texas A&M University, College Station Texas- B.S. in Botany

 

PROFESSIONAL EXPERIENCE

2005 to Present. Research Professional III in the Meagher laboratory examining the genetics, epigenetics, evolution, gene expression, and molecular cell biology of the actin, actin-related protein, profilin and ADF/cofilin families in plants.

1999 to 2005. Research Coordinator II in the Meagher laboratory examining the evolution, expression, and molecular cell biology of the actin, profilin and ARP gene families in plants.


1986 to 1999. Research Coordinator I in the Meagher laboratory examining the expression and molecular cell biology of the actin and profilin gene families in plants.

PUBLICATIONS (45 peer reviewed research articles and book chapters)

Meagher, R., Kandasamy, M., Smith, A., and McKinney, E. (2010). Nuclear Actin-Related Proteins at the Core of Epigenetic Control. Plant Signaling and Behavior Invited Review - In Press

Kandasamy, M.K., McKinney, E.C., Deal, R.B., Smith, A.P., and Meagher, R.B. (2009a). Arabidopsis actin-related protein ARP5 in multicellular development and DNA repair. Dev Biol 335, 22-32. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19679120

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2009b). A Single Vegetative Actin Isovariant Overexpressed under the Control of Multiple Regulatory Sequences Is Sufficient for Normal Arabidopsis Development. Plant Cell 21, 701-18. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19304937

Meagher, R.B., Kandasamy, M.K., McKinney, E.C., and Roy, E. (2009). Chapter 5. Nuclear actin-related proteins in epigenetic control. Int Rev Cell Mol Biol 277, 157-215. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19766970

Price, P.W., McKinney, E.C., Wang, Y., Sasser, L.E., Kandasamy, M.K., Matsuuchi, L., Milcarek, C., Deal, R.B., Culver, D.G., and Meagher, R.B. (2009). Engineered cell surface expression of membrane immunoglobulin as a means to identify monoclonal antibody-secreting hybridomas. J Immunol Methods 343, 28-41. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19187782

Burgos-Rivera, B., Ruzicka, D.R., Deal, R.B., McKinney, E.C., King-Reid, L., and Meagher, R.B. (2008). ACTIN DEPOLYMERIZING FACTOR9 controls development and gene expression in Arabidopsis. Plant Mol Biol 68, 619-32. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18830798

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2008). ACTIN-RELATED PROTEIN8 encodes an F-box protein localized to the nucleolus in Arabidopsis. Plant Cell Physiol 49, 858-63. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18385164

Meagher, R.B., Kandasamy, M.K., and McKinney, E.C. (2008). Multicellular development and protein-protein interactions. Plant Signal Behav 3, 333-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19841663

Deal, R.B., Topp, C.N., McKinney, E.C., and Meagher, R.B. (2007). Repression of flowering in Arabidopsis requires activation of FLOWERING LOCUS C expression by the histone variant H2A.Z. Plant Cell 19, 74-83. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17220196

Kandasamy, M.K., Burgos-Rivera, B., McKinney, E.C., Ruzicka, D.R., and Meagher, R.B. (2007). Class-specific interaction of profilin and ADF isovariants with actin in the regulation of plant development. Plant Cell 19, 3111-26. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17933902

Meagher, R.B., Kandasamy, M.K., Deal, R.B., and McKinney, E.C. (2007). Actin-related proteins in chromatin-level control of the cell cycle and developmental transitions. Trends Cell Biol 17, 325-32. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17643304

Ruzicka, D.R., Kandasamy, M.K., McKinney, E.C., Burgos-Rivera, B., and Meagher, R.B. (2007). The ancient subclasses of ArabidopsisACTIN DEPOLYMERIZING FACTOR genes exhibit novel and differential expression. Plant J 52, 460-72. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17877706

Dhankher, O.P., Rosen, B.P., McKinney, E.C., and Meagher, R.B. (2006). Hyperaccumulation of arsenic in the shoots of Arabidopsis silenced for arsenate reductase (ACR2). Proc Natl Acad Sci U S A 103, 5413-5418. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16567632

Deal, R.B., Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2005). The Nuclear Actin-Related Protein ARP6 Is a Pleiotropic Developmental Regulator Required for the Maintenance of FLOWERING LOCUS C Expression and Repression of Flowering in Arabidopsis. Plant Cell 17, 2633-2646. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16141450

Kandasamy, M.K., Deal, R.B., McKinney, E.C., and Meagher, R.B. (2005a). Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has multiple effects on plant development, including early flowering and delayed floral senescence. Plant J 41, 845-58. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15743449

Kandasamy, M.K., McKinney, E.C., Deal, R.B., and Meagher, R.B. (2005b). Arabidopsis ARP7 is an essential actin-related protein required for normal embryogenesis, plant architecture, and floral organ abscission. Plant Physiol 138, 2019-32. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16040647

Kim, T., Balish, R.S., Heaton, A.C., McKinney, E.C., Dhankher, O.P., and Meagher, R.B. (2005). Engineering a root-specific, repressor-operator gene complex. Plant Biotechnol J 3, 571-82. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17147628

Meagher, R.B., Deal, R.B., Kandasamy, M.K., and McKinney, E.C. (2005). Nuclear actin-related proteins as epigenetic regulators of development. Plant Physiol 139, 1576-85. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16339804

Pawloski, L.C., Deal, R.B., McKinney, E.C., Burgos-Rivera, B., and Meagher, R.B. (2005). Inverted repeat PCR for the rapid assembly of constructs to induce RNA interference. Plant & Cell Physiol 46, 1872-1878. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16120684

Kandasamy, M.K., Deal, R.B., McKinney, E.C., and Meagher, R.B. (2004). Plant actin-related proteins. Trends Plant Sci 9, 196-202. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15063870

Meagher, R.B., Kandasamy, M.K., Deal, R.B., and McKinney, E.C. (2004). Nuclear actin-related proteins modulate multiple diverse developmental pathways in Arabidopsis. Mol. Biol. Cell 15, 328a-329a. <Go to ISI>://000224648802542

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2003). Cell cycle-dependent association of Arabidopsis actin-related proteins AtARP4 and AtARP7 with the nucleus. Plant J 33, 939-48. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12609034

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2002a). Plant profilin isovariants are distinctly regulated in vegetative and reproductive tissues. Cell Motil Cytoskeleton 52, 22-32. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11977080

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2002b). Functional nonequivalency of actin isovariants in Arabidopsis. Mol Biol Cell 13, 251-61. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11809837

McKinney, E.C., Kandasamy, M.K., and Meagher, R.B. (2002). Arabidopsis contains ancient classes of differentially expressed actin-related protein genes. Plant Physiol 128, 997-1007. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11891255

Kandasamy, M.K., Gilliland, L.U., McKinney, E.C., and Meagher, R.B. (2001). One plant actin isovariant, ACT7, is induced by auxin and required for normal callus formation. Plant Cell 13, 1541-54. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11449050

McKinney, E.C., Kandasamy, M.K., and Meagher, R.B. (2001). Small changes in the regulation of one Arabidopsis profilin isovariant, PRF1, alter seedling development. Plant Cell 13, 1179-91. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11340190

Meagher, R.B., McKinney, E.C., and Kandasamy, M.K. (2000). The significance of diversity in the plant actin gene family: Studies in Arabidopsis. In: Actin: A dynamic framework for multiple plant cell functions, C.J. Staiger, F. Baluska, D. Volkmann, and P. Barlow, eds (Dordrecht, The Netherlands: Klewer Academic Publishers), pp. 3-27.

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (1999). The late pollen-specific actins in angiosperms. Plant J 18, 681-91. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10417720

Meagher, R.B., McKinney, E.C., and Kandasamy, M.K. (1999a). Isovariant dynamics expand and buffer the responses of complex systems: the diverse plant actin gene family. Plant Cell 11, 995-1006. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10368172

Meagher, R.B., McKinney, E.C., and Vitale, A.V. (1999b). The evolution of new structures: clues from plant cytoskeletal genes. Trends Genet 15, 278-84. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10390627

Gilliland, L.U., McKinney, E.C., Asmussen, M.A., and Meagher, R.B. (1998). Detection of deleterious genotypes in multigenerational studies. I. Disruptions in individual Arabidopsis actin genes. Genetics 149, 717-25. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9611186

McKinney, E.C., and Meagher, R.B. (1998). Members of the Arabidopsis actin gene family are widely dispersed in the genome. Genetics 149, 663-75. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9611182

Huang, S., An, Y.Q., McDowell, J.M., McKinney, E.C., and Meagher, R.B. (1997). The Arabidopsis ACT11 actin gene is strongly expressed in tissues of the emerging inflorescence, pollen, and developing ovules. Plant Mol Biol 33, 125-39. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9037165

An, Y.Q., Huang, S., McDowell, J.M., McKinney, E.C., and Meagher, R.B. (1996a). Conserved expression of the Arabidopsis ACT1 and ACT3 actin subclass in organ primordia and mature pollen. Plant Cell 8, 15-30. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8597657

An, Y.Q., McDowell, J.M., Huang, S., McKinney, E.C., Chambliss, S., and Meagher, R.B. (1996b). Strong, constitutive expression of the Arabidopsis ACT2/ACT8 actin subclass in vegetative tissues. Plant J 10, 107-21. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8758981

Huang, S., An, Y.Q., McDowell, J.M., McKinney, E.C., and Meagher, R.B. (1996). The Arabidopsis thaliana ACT4/ACT12 actin gene subclass is strongly expressed throughout pollen development. Plant J 10, 189-202. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8771777

McDowell, J.M., An, Y.Q., Huang, S., McKinney, E.C., and Meagher, R.B. (1996a). The Arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli. Plant Physiol 111, 699-711. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8754679

McDowell, J.M., Huang, S., McKinney, E.C., An, Y.Q., and Meagher, R.B. (1996b). Structure and evolution of the actin gene family in Arabidopsis thaliana. Genetics 142, 587-602. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8852856

Senecoff, J.F., McKinney, E.C., and Meagher, R.B. (1996). De novo purine synthesis in Arabidopsis thaliana. II. The PUR7 gene encoding 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole synthetase is expressed in rapidly dividing tissues. Plant Physiol 112, 905-17. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8938402

McKinney, E.C., Ali, N., Traut, A., Feldmann, K.A., Belostotsky, D.A., McDowell, J.M., and Meagher, R.B. (1995). Sequence-based identification of T-DNA insertion mutations in Arabidopsis: actin mutants act2-1 and act4-1. Plant J 8, 613-22. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7496405

Valenta, R., Ferreira, F., Grote, M., Swoboda, I., Vrtala, S., Duchene, M., Deviller, P., Meagher, R.B., McKinney, E., Heberle-Bors, E., and et al. (1993). Identification of profilin as an actin-binding protein in higher plants. J Biol Chem 268, 22777-81. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7693678

McLean, B.G., Huang, S.R., McKinney, E.C., and Meagher, R.B. (1990). Plants contain highly divergent actin isovariants. Cell Motil Cytoskeleton 17, 276-90. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2076545

Allen, R.D., Cohen, E.A., Vonder Haar, R.A., Adams, C.A., Ma, D.P., Nessler, C.L., and Thomas, T.L. (1987). Sequence and expression of a gene encoding an albumin storage protein in sunflower. Mol Gen Genet 210, 211-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2830455

Allen, R.D., Cohen, E.A., Orth, K.A., Vonder Haar, R.A., Ma, D.P., Nessler, C.L., and Thomas., T.L. (1986). Expression of Embryo Specific Genes in Sunflower. In Molecular Approaches to Developmental Biology.  In:  R. Firtel, and E. Davidson, eds (New York: Alan R. Liss, Inc.), 415-424.


 

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