Shiyun Xiao
Assistant Research Scientist
M.D./Ph.D. (2001) Peking University
Phone: 706-542-8509
Email: shiyun@uga.edu

Research Interests
I am interested in development and function of T cell and immune associated diseases resulted by developmental defect of thymus or thymocyte. My current projects focus on the developmental characterization of phenotype and function of T cells affected by mutation of Foxn1 gene.
  • Xiao, S., D.M. Su and N.R. Manley (in press). Atypical memory phenotype T cells with low homeostatic potential and impaired TCR signaling and Treg function in Foxn1Δ/Δ mutant mice. Journal of Immunology.
  • Xiao, S., D.M. Su and N.R. Manley (in press). T cell development from kit-negative progenitors in the Foxn1Δ/Δ mutant thymus. Journal of Immunology.
  • Gordon J., S. Xiao, B. Hughes, 3rd, D.M. Su, S.P. Navarre, BG Condie and N.R. Manley. 2007. Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev Biol. 7: 69.
  • Morimoto, M., M. Morimoto, J. Whitmire, S. Xiao, R.M. Anthony, H. Mirakami, R.A. Star, J.F. Urban Jr. and W.C. Gause. 2004. Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. Journal of Immunology 172: 2424-2430.
  • Ekkens, M.J., Z. Liu, Q. Liu, J. Whitmire, S. Xiao, A. Foster, J. Pesce, J. BanNoy, A.H. Sharpe, J.G. Urban and W.C. Gause. 2003. The role of
    OX40 interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. Journal of Immunology 170: 384-393.
  • Xiao, S.Y., Y. Li, X.-P. Qian, Y.-D. Wang and W.-F. Chen. 2003. Characteristics of TCRaβ+CD4-CD8- thymocytes in fetal thymic organ culture. Progress in Natural Science. 13: 419-423.
  • Xiao, S.Y., Y. Li and W.-F. 2003. Kinetic of thymocyte developmental process in fetal and neonatal mice. Cell Research 13: 265-273.
  • Xiao, S.Y., L. Gao, Q. Guo and W.-F. Chen. 2002. The developmental research of fetal thymocyte in FTOC in vitro. Chinese Journal of Microbiology and Immunology 22: 65.
  • Xiao, S.Y., and W.-F. Chen. 2000. Enhancement of suboptimal does of ConA-mediated activation and apoptosis of thymocyte by immobilized PF18-3 mAb. Chinese Journal of Microbiology and Immunology 20: 393.