Daniel Promislow
Department of Pathology, University of Washington
Ph.D. (1990) Oxford University
Phone: 706-542-8000
Email: promislo@uw.edu
See my Laboratory Home Page

Research Interests
Our lab works on the evolution of aging. We are interested in the forces that maintain genetic variation for patterns of aging in natural populations. Recent projects in the lab have included studies of flies, yeast, dogs, and marmosets, and have used experimental, theoretical and bioinformatic techniques. At present, we are particularly interested in the effects of aging on genomic and metabolomic network structure and function.
  • Hoffman, J.M., K.E. Creevy and D.E.L. Promislow. 2013. Reproductive Capability is Associated with Lifespan and Cause of Death in Companion Dogs. PLOS One.
  • Kraus, Cornelia, Samuel Pavard, Daniel Promislow. 2012. The size-lifespan trade-off decomposed: Why large dogs die young. American Naturalist
  • Moorad, J.A., D.E.L. Promislow, N. Flesness and R.A. Miller. 2012. A comparative assessment of univariate longevity measures using zoological animal records. Aging Cell. DOI: 10.1111/j.1474-9726.2012.00861.x
  • Fleming, J.M., K.E. Creevy and D.E.L. Promislow. 2011. Mortality in North American dogs from 1984-2004: An investigation into breed- and age-related causes of death. Journal of Veterinary Internal Medicine 25: 187198.
  • Moorad, J.A., D.E.L. Promislow, K.R. Smith and M.J. Wade. 2011. Mating system change reduces the strength of sexual selection in an American frontier population of the 19th century. Evolution and Human Behavior 32: 147-155.
  • Moorad, J.A. and D.E.L. Promislow. 2011. Evolutionary demographic and quantitative genetics: Age-specific survival as a threshold trait.Proc. R. Soc. B (London). 278: 144-151.
  • Soltow, Q.A., D.P. Jones and D.E.L. Promislow. 2010. A network perspective on metabolism and aging. Integrative and Comparative Biology. doi: 10.1093/icb/icq094.
  • Moorad, J.A. and D.E.L. Promislow. 2010. Evolutionary demographic and quantitative genetics: Age-specific survival as a threshold trait. Proc. R. Soc. (London) doi: 10.1098/rspb.2010.0992.
  • Ronce, O. and D.E.L. Promislow. 2010. Kin competition, natal dispersal and the moulding of senescence by natural selection. Proc. R. Soc. (London) doi: 10.1098/rspb.2010.1095.
  • Moorad, J.A. and D.E.L. Promislow. 2009. What can genetic variance tell us about the evolution of senescence? Proc. R. Soc. B. (London) 276(1665): 2271-2278.
  • Linder, J.E. and Promislow, D.E.L. 2009. Cross-generational fitness effects of infection in Drosophila melanogaster. Fly 3: 143-150.
  • Moorad, J.A. and D.E.L. Promislow. 2008. A theory of age-dependent mutation and senescence. Genetics 179: 2061-73.
  • Smith, E.D., M. Tsuchiya, L.A. Fox, N. Dang, D. Hu, E.O. Kerr, E.D. Johnston, B.N. Tchao, D.N. Pak, K.L. Welton, D.E.L. Promislow, J.H. Thomas, M. Kaeberlein and B.K. Kennedy. 2008. Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Research 18: 564-570.
  • Linder, J.E., K.A. Owers and D.E.L. Promislow. 2008. The effects of temperature on host-pathogen interactions in D. melanogaster: Who benefits? Journal of Insect Physiology 54: 297-308.
  • Corby-Harris, V. and D.E.L. Promislow. 2008. Host ecology shapes geographical variation for resistance to bacterial infection in Drosophila melanogaster. J. Anim. Ecol. 77: 768-76.
  • Kuo, C.-H., V. Corby-Harris and D.E.L. Promislow. 2008. The unavoidable costs and unexpected benefits of parasitism: population and metapopulation models of parasite-mediated competition. Journal of Theoretical Biology 250: 244-256.
  • Charmantier, A., A.J. Keyser and D.E.L. Promislow. 2007. First evidence for heritable variation in cooperative breeding behaviour. Proc. R. Soc. 274: 1757-1761.
  • Corby-Harris, V., A.C. Pontaroli, L.J. Shimkets, J.L. Bennetzen, K.E. Habel and D.E.L. Promislow. 2007. The geographical distribution and diversity of microbes associated with natural populations of Drosophila melanogaster. Applied and Environmental Microbiology.
  • Chandler, R., L. Wolfe and D.E.L. Promislow. 2007. Survival of the Fittest: The Chicago Guide to Landing an Academic Biology Job. University of Chicago Press.
  • Burger, J.M.S., D.S. Hwangbo, V. Corby-Harris and D.E.L. Promislow. 2007. The functional costs and benefits of dietary restriction in Drosophila. Aging Cell 6: 63-71.
  • Fedorka, K., J. Linder and D.E.L. Promislow. 2007. Post-mating disparity between potential and realized immune response in Drosophila melanogaster. Proc.R. Soc. Series B (London). 274: 1211-1217.
  • Corby-Harris, V., K.E. Habel, F.G. Ali and D.E.L. Promislow. 2007. Alternative measures of response to Pseudomonas aeruginosa infection in Drosophila melanogaster. Journal of Evolutionary Biology 20: 526-533.
  • Proulx, S.R., S. Nuzhdin and D.E.L. Promislow. 2007. Direct selection on genetic robustness revealed in the yeast transcriptome. PLoS ONE 2(9): e911.
  • Beck, C.W. and D.E.L. Promislow. 2007. Evolution of female preference for younger males. PLoS ONE 2(9): e939.
  • Promislow, D.E.L. and A. Bronikowski. 2006. Evolutionary genetics of senescence. In: Evolutionary Genetics: Concepts and Case Studies. C.W. Fox and J.B. Wolf (eds). Oxford University Press.
  • Burger, J.M.S. and D.E.L. Promislow. 2006. Are functional and demographic senescence genetically independent? Experimental Gerontology 41: 1108-1116.
  • Proulx, S., P. Phillips and D.E.L. Promislow. 2005. The ecology and evolution of networks. Trends in Ecology and Evolution 20: 345-353.
  • Promislow, D.E.L. 2005. A regulatory network analysis of phenotypic plasticity in yeast. American Naturalist 165: 515-523.
  • Promislow, D.E.L. 2004. Protein networks, pleiotropy and the evolution of senescence. Proc. R. Soc. (London) 271: 1225-1234.
  • Promislow, D.E.L. 2003. Mate choice, sexual conflict and evolution of senescence. Behavior Genetics 33: 191-201.
  • Spencer, C.C, C.E. Howell, A.R. Wright and D.E.L. Promislow. 2003. Testing an 'aging gene' in long-lived Drosophila strains: Increased longevity depends on sex and genetic background. Aging Cell 2: 123-130.
  • Beck, C.W., B. Shapiro, S. Choksi and D.E.L. Promislow. 2002. A genetic algorithm approach to study the evolution of female preference based on male age. Evolutionary Ecology Research 4: 275-292.
  • "The genetic architecture of somatic mutation rate," NSF
  • "Causes and consequences of aging in metabolomic networks," American Federation for Aging Research
  • "A metabolomic model of aging in the common marmoset," NIH