| David Hall
Ph.D. (1995) Duke University
See my Laboratory Home Page
I am interested in a variety of evolutionary questions that can be addressed using mathematical models or experimental evolution. Currently I am pursuing three primary areas of research. The first addresses the evolution of sex chromosomes. I am developing mathematical models to address the loss of genes from a neo Y chromosome. In addition, in collaboration with Kelly Dyer, another faculty member in the department, I am working on mathematical models of the evolution of sex ratio drive systems. The second research focus examines the rate of molecular evolution at loci experiencing direct versus indirect selection in social insect systems, again using mathematical models. Third, I am utilizing budding yeast, Saccharomyces cerevisiae, to study spontaneous mutations using a combination of both mutation-accumulation and adaptation experiments. In addition to these primary areas of research, my lab works on several side-projects, some of which are described on my lab site.
- Hall, D.W., S.V. Jin, and M.A.D. Goodisman. Kin selection, genomics, and caste-antagonistic pleiotropy. In press. Biology Letters.
- Hall, D.W., S. Fox, J.J. Kuzdzal-Fick, J.E. Strassmann, and D.C. Queller. 2013. The Rate and Effects of Spontaneous Mutation on Fitness Traits in the Social Amoeba, Dictyostelium discoideum. Genes, Genomes, Genetics. doi: 10.1534/g3.113.005934.
- Robinson, J.D., D.W. Hall, and J.P. Wares. 2013. Approximate Bayesian estimation of extinction rate in the Finnish Daphnia magna metapopulation. Molecular Ecology 22: 2627-2639.
- Hall, D.W. and M.L. Wayne. 2012. Ohno's "peril of hemizygosity" revisited: gene loss, dosage compensation, and mutation. Genome Biology and Evolution 5: 1-15. doi: 10.1093/gbe/evs106.
- Robinson, J.D., C.R. Haag, D.W. Hall, V.I. Pajunen, and J.P. Wares. 2012. Genetic estimates of population age in the Finnish Daphnia magna Straus, 1820 metapopulation: results from simulated and empirical datasets. Journal of Heredity. doi: 10.1093/jhered/ess063.
- Hall, D.W. and M.A.D. Goodisman. 2012. The effects of direct versus indirect selection and multiple mating on rates of molecular evolution in social insects. Evolution 66: 2080-2093.
- Jackwood, M.W., D.W. Hall, and A. Handel. 2012. Molecular evolution and emergence of gammacoronaviruses. Infection, Genetics and Evolution 12: 1305-1311.
- Zakas, C. and D.W. Hall. 2012. Asymmetric dispersal and the maintenance of larval dimorphism in the benthic polychaete Streblospio benedicti. Integrative and Comparative Biology 52: 197-212. doi: 10.1093/icb/ics055.
- Stanger-Hall, K.F. and Hall, D.W. 2011. Abstinence-only education and teen pregnancy rates: Why we need comprehensive sex education in the U.S. PLoS ONE 6(10): e24658. doi:10.1371/journal.pone.0024658.
- Hall, D.W. and S.B. Joseph. 2010. A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae. Genetics 185: 1397-1409.
- Hall, D.W., M. Agan and S.C. Pope. 2010. Fitness epistasis among six biosynthetic loci in the budding yeast Saccharomyces cerevisiae. Journal of Heredity 101: S75 - S84.
- Moorad, J.A. and D.W. Hall. 2009. Age-dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy. Journal of Evolutionary Biology 22: 2409-2419.
- Moorad, J.A. and D.W. Hall. 2009. Mutation accumulation, soft selection, and the middle-class neighborhood. Genetics 182: 1387-1389.
- Hall, D.W., R. Mahmoudizad, A.W. Hurd and S.B. Joseph. 2008. Spontaneous mutations in diploid yeast: another thousand cell-generations. Genetical Research 90: 229-241.
- Hall, D.W. and T.M. Harvey. 2007. Mortality at a night roost of Great-tailed Grackles and European Starlings during a Spring hail storm. The Wilson Journal of Ornithology 119: 309-312.
- Hall, D.W. and M. Kirkpatrick, 2006. Reinforcement and sex linkage. Evolution 60: 908-921.
- Mank, J.E., D.W. Hall, M. Kirkpatrick and J.C. Avise. 2006. Sex chromosomes and male ornaments: A comparative evaluation in ray-finned fishes. Proceedings of the Royal Society of London, Series B 273: 233-236.
- Hall, D.W. 2004. Meiotic drive and sex chromosome cycling. Evolution 58: 925-931.
- Joseph, S. and D.W. Hall. 2004. Spontaneous mutations in diploid yeast: More beneficial than expected. Genetics 168: 1817-1825.
- Kirkpatrick, M.K. and D.W. Hall. 2004. Male-biased mutation, sex linkage, and the rate of adaptive evolution. Evolution 58: 437-440.
- Kirkpatrick, M.K. and D.W. Hall. 2004. Sexual selection and sex linkage. Evolution 58: 683- 691.
- Hall, D.W. 2000. The evolution of haploid, diploid and polymorphic haploid-diploid life cycles. The role of meiotic mutation. Genetics 156: 893-896.
- Hall, D.W., M. Kirkpatrick and B. West. 2000. Runaway sexual selection when female preferences are directly selected. Evolution 54: 1862-1869.