NIH T32 Training Grant 2017-18
I'm studying transcriptional regulation during limb and genital development in amniotes, using chicks, mice, and Anolis lizards as distantly-related species to identify deeply conserved mechanisms of development. Previous ChIP-seq data suggested that many limb enhancers are active in the genital tubercle – the primordium from which the penis and clitoris develop. My research focuses on a transcription factor encoded by Islet1, which plays a crucial role in both hindlimb and genital tubercle development. Using ChIP-seq and RNA-seq, I aim to identify the direct targets of ISL1 regulation, find targets that are conserved across species, and assess the degree of enhancer sharing between tissues.