B.S. Appalachian State University (2015)
- Introduction to Genetics (GENE3200)
Al-Omari, A., Griffith, J., Judge, M., Taha, T., Arnold, J., and Schüttler, H.B. 2015. Discovering a Regulatory Network Topology Using Ensemble Methods on GPGPUs with Special Reference to the Biological Clock of Neurospora crassa. IEEE Access 3:27-42.
The circadian clock is an emergent property controlling gene expression in organisms ranging from single-celled prokaryotes to the individual cells of higher eukaryotes like plants and humans. The clock aligns regular processes on the single-cell, tissue and organismal levels so that they occur in a time-dependent fashion with respect to each other and to daily oscillations in the natural environment (like daylight). I am broadly interested in elucidating the clock's inputs and outputs. Specifically, I am developing genetic (including transcriptional reporter assays) and metabolomic (including NMR, HPLC-NMR/MS) screens towards answering the following:
- - How do cells in the same microenvironment synchronize their clocks?
- - Can we isolate an intercellular chemical signal which explains this behavior?
- - What are the metabolic/transcriptional pathways which produce and respond to this signal?
- - What is its physiological relevance of local synchronization, and is it conserved in other systems?